Linked Life Data

18452032

Source:http://linkedlifedata.com/resource/pubmed/id/18452032

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-7-30
pubmed:abstractText
MicroRNAs (miRNAs) regulate gene expression in a post-transcriptional sequence-specific manner. In order to better understand the possible roles of miRNAs in central nervous system (CNS) development, we examined the expression profile of 104 miRNAs during murine brain development. We obtained brain samples from animals at embryonic days (E) E15, E17, and postnatal days (P) P1 and P7. Total RNA was isolated from tissue and used to obtain mature miRNAs by reverse transcription. Our results indicate that there is a group of 12 miRNAs that show a distinct expression profile, with the highest expression during embryonic stages and decreasing significantly during development. This profile suggests key roles in processes occurring during early CNS development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0895-8696
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
MicroRNA expression profile in murine central nervous system development.
pubmed:affiliation
Department of Medical Genetics, Faculty of Medical Sciences, University of Campinas-UNICAMP, Tessália Vieira de Camargo 126, Campinas, Sao Paulo, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't