Linked Life Data

18452010

Source:http://linkedlifedata.com/resource/pubmed/id/18452010

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2008-5-2
pubmed:abstractText
A new series of diterpenes, the jatrophanes euphoscopin M (1), euphoscopin N (2) and euphornin L (3), and the lathyrane euphohelioscopin C (7) were isolated from plants of Euphorbia helioscopia L., together with four other known analogues, euphoscopin C (4), euphornin (5), epieuphoscopin B (6) and euphohelioscopin A (8). The new compound stereostructures were elucidated by NMR analysis and computational data. The resulting isolated diterpenes were found to be potent inhibitors of P-glycoprotein (ABCB1), while showing an absence of significant activity against BCRP (ABCG2), despite the high substrate overlapping of these transporters, thus including them in the third-generation class of specific multidrug transporter modulators.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1477-0520
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1756-62
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators.
pubmed:affiliation
DISTAAM, Università degli Studi del Molise, Via F. De Sanctis, I-86100 Campobasso, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't