Linked Life Data

18451339

Source:http://linkedlifedata.com/resource/pubmed/id/18451339

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2008-6-6
pubmed:abstractText
Abdominal aortic aneurysm (AAA) is histologically characterized by medial degeneration and various degrees of chronic adventitial inflammation, although the mechanisms for progression of aneurysm are poorly understood. In the present study, we carried out histological study of AAA tissues of patients, and interventional animal and cell culture experiments to investigate a role of mast cells in the pathogenesis of AAA. The number of mast cells was found to increase in the outer media or adventitia of human AAA, showing a positive correlation between the cell number and the AAA diameter. Aneurysmal dilatation of the aorta was seen in the control (+/+) rats following periaortic application of calcium chloride (CaCl2) treatment but not in the mast cell-deficient mutant Ws/Ws rats. The AAA formation was accompanied by accumulation of mast cells, T lymphocytes and by activated matrix metalloproteinase 9, reduced elastin levels and augmented angiogenesis in the aortic tissue, but these changes were much less in the Ws/Ws rats than in the controls. Similarly, mast cells were accumulated and activated at the adventitia of aneurysmal aorta in the apolipoprotein E-deficient mice. The pharmacological intervention with the tranilast, an inhibitor of mast cell degranulation, attenuated AAA development in these rodent models. In the cell culture experiment, a mast cell directly augmented matrix metalloproteinase 9 activity produced by the monocyte/macrophage. Collectively, these data suggest that adventitial mast cells play a critical role in the progression of AAA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1524-4571
pubmed:author
pubmed:issnType
Electronic
pubmed:day
6
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1368-77
pubmed:meshHeading
pubmed-meshheading:18451339-Animals, pubmed-meshheading:18451339-Anthranilic Acids, pubmed-meshheading:18451339-Aortic Aneurysm, Abdominal, pubmed-meshheading:18451339-Apolipoproteins E, pubmed-meshheading:18451339-Calcium Chloride, pubmed-meshheading:18451339-Cell Count, pubmed-meshheading:18451339-Cell Degranulation, pubmed-meshheading:18451339-Cells, Cultured, pubmed-meshheading:18451339-Connective Tissue, pubmed-meshheading:18451339-Disease Models, Animal, pubmed-meshheading:18451339-Disease Progression, pubmed-meshheading:18451339-Humans, pubmed-meshheading:18451339-Mast Cells, pubmed-meshheading:18451339-Matrix Metalloproteinase 9, pubmed-meshheading:18451339-Mice, pubmed-meshheading:18451339-Mice, Knockout, pubmed-meshheading:18451339-Rats, pubmed-meshheading:18451339-Rats, Mutant Strains, pubmed-meshheading:18451339-T-Lymphocytes
pubmed:year
2008
pubmed:articleTitle
Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysm.
pubmed:affiliation
Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki 5200 Kihara Kiyotake, Miyazaki 889-1692, Japan. ttsuruda@med.miyazaki-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't