Linked Life Data

18451325

Source:http://linkedlifedata.com/resource/pubmed/id/18451325

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-7-2
pubmed:abstractText
Periodontitis is an infectious disease, where putative periodontopathogens trigger chronic inflammatory and immune responses against periodontal structures, in which an unbalanced host response is also determinant to the disease outcome. It is reasonable to assume that patient susceptibility to periodontal tissue destruction could be determined by the balance between the response against periodontopathogens and regulatory mechanisms of these events mediated by suppressive T cells. In the present study, we identified and characterized natural regulatory T cells (Tregs) in the inflammatory infiltrate of human chronic periodontitis (CP) with emphasis on phenotypic analyses that were carried out to address the participation of Tregs in CP. Results showed that patients with CP presented increased frequency of T lymphocytes and CD4+CD25+ T cells in the inflammatory infiltrate of gingival tissues. These cells exhibited the phenotypic markers of Tregs such as forkhead box p3 (Foxp3), CTLA-4, glucocorticoid-inducible TNFR, CD103, and CD45RO and seemed to be attracted to the inflammation site by the chemokines CCL17 and CCL22, as their expression and its receptor CCR4 were increased in CP patients. Moreover, besides the increased detection of Foxp3 mRNA, diseased tissues presented high expression of the regulatory cytokines IL-10 and TGF-beta. In addition, the inflammatory infiltrate in CP biopsies was composed of CD25+Foxp3+ and CD25+TGF-beta+ cells, thus corroborating the hypothesis of the involvement of Tregs in the pathogenesis of CP. Finally, these results indicate that Tregs are found in the chronic lesions and must be involved in the modulation of local immune response in CP patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0741-5400
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-8
pubmed:meshHeading
pubmed-meshheading:18451325-Adult, pubmed-meshheading:18451325-Antigens, CD4, pubmed-meshheading:18451325-Cell Movement, pubmed-meshheading:18451325-Chemokine CCL17, pubmed-meshheading:18451325-Chemokine CCL22, pubmed-meshheading:18451325-Chronic Disease, pubmed-meshheading:18451325-Cytokines, pubmed-meshheading:18451325-Forkhead Transcription Factors, pubmed-meshheading:18451325-Gingiva, pubmed-meshheading:18451325-Humans, pubmed-meshheading:18451325-Immunohistochemistry, pubmed-meshheading:18451325-Inflammation, pubmed-meshheading:18451325-Interleukin-2 Receptor alpha Subunit, pubmed-meshheading:18451325-Microscopy, Confocal, pubmed-meshheading:18451325-Periodontitis, pubmed-meshheading:18451325-Phenotype, pubmed-meshheading:18451325-Receptors, Chemokine, pubmed-meshheading:18451325-T-Lymphocytes, Regulatory
pubmed:year
2008
pubmed:articleTitle
Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis.
pubmed:affiliation
Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't