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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-5-2
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pubmed:abstractText |
Orally active anticancer drugs have great advantages for the treatment of cancer. Compelling data suggest that heparin exhibits critical antimetastatic effects via interference with P-selectin-mediated cell-cell binding. However, heparin should be given parenterally because it is not orally absorbed. Here, we evaluated the inhibitory effect of orally absorbable heparin derivative (LHD) on experimentally induced metastasis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2841-9
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pubmed:meshHeading |
pubmed-meshheading:18451252-Administration, Oral,
pubmed-meshheading:18451252-Animals,
pubmed-meshheading:18451252-Cell Line, Tumor,
pubmed-meshheading:18451252-Deoxycholic Acid,
pubmed-meshheading:18451252-Disease Models, Animal,
pubmed-meshheading:18451252-Heparin, Low-Molecular-Weight,
pubmed-meshheading:18451252-Humans,
pubmed-meshheading:18451252-Lung Neoplasms,
pubmed-meshheading:18451252-Melanoma, Experimental,
pubmed-meshheading:18451252-Mice,
pubmed-meshheading:18451252-Mice, Inbred C57BL,
pubmed-meshheading:18451252-Neoplasm Metastasis,
pubmed-meshheading:18451252-P-Selectin
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pubmed:year |
2008
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pubmed:articleTitle |
Antimetastatic effect of an orally active heparin derivative on experimentally induced metastasis.
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pubmed:affiliation |
College of Pharmacy, Seoul National University, Seoul, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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