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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-5-2
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pubmed:abstractText |
Early events in colorectal tumorigenesis include mutation of the adenomatous polyposis coli (APC) gene and epigenetic hypermethylation with transcriptional silencing of the O(6)-methylguanine DNA methyltransferase (MGMT), human mut L homologue 1 (hMLH1), and P16/CDKN2A genes. Epigenetic alterations affect genetic events: Loss of MGMT via hypermethylation reportedly predisposes to guanine-to-adenine or cytosine-to-thymine (G:C-->A:T) transition mutations in KRAS and P53, and silencing of hMLH1 leads to high levels of microsatellite instability (MSI-H)/mutator phenotype, suggesting that epigenetic-genetic subtypes exist.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/BRAF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Modification Methylases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Repair Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/KRAS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MGMT protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins B-raf,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:ChanAnnie S YAS,
pubmed-author:ChanTsun LeungTL,
pubmed-author:ChanYee WaiYW,
pubmed-author:ChirieacLucian RLR,
pubmed-author:HamanakaYuichiroY,
pubmed-author:HamiltonStanley RSR,
pubmed-author:HinodaYujiY,
pubmed-author:IssaJean-Pierre JJP,
pubmed-author:KondoYutakaY,
pubmed-author:LeungSuet YiSY,
pubmed-author:MorrisJeffreyJ,
pubmed-author:RashidAsifA,
pubmed-author:ShannonRhonda LRL,
pubmed-author:ShenLanlanL,
pubmed-author:SuehiroYutakaY,
pubmed-author:WangXuemeiX,
pubmed-author:WebbC ReneeCR,
pubmed-author:WongChi WaiCW,
pubmed-author:WuTsung-TehTT,
pubmed-author:YuenSiu TsanST
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2560-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18451217-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:18451217-Colorectal Neoplasms,
pubmed-meshheading:18451217-CpG Islands,
pubmed-meshheading:18451217-DNA Methylation,
pubmed-meshheading:18451217-DNA Modification Methylases,
pubmed-meshheading:18451217-DNA Repair Enzymes,
pubmed-meshheading:18451217-Epigenesis, Genetic,
pubmed-meshheading:18451217-Female,
pubmed-meshheading:18451217-Genes, APC,
pubmed-meshheading:18451217-Genes, p53,
pubmed-meshheading:18451217-Genes, ras,
pubmed-meshheading:18451217-Humans,
pubmed-meshheading:18451217-Male,
pubmed-meshheading:18451217-Middle Aged,
pubmed-meshheading:18451217-Mutation,
pubmed-meshheading:18451217-Nuclear Proteins,
pubmed-meshheading:18451217-Promoter Regions, Genetic,
pubmed-meshheading:18451217-Proto-Oncogene Proteins,
pubmed-meshheading:18451217-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:18451217-Tumor Suppressor Proteins,
pubmed-meshheading:18451217-Wnt Proteins,
pubmed-meshheading:18451217-ras Proteins
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pubmed:year |
2008
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pubmed:articleTitle |
Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.
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pubmed:affiliation |
Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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