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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-6-27
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pubmed:abstractText |
Five new cembranoids, designated grandilobatins A-E (1- 5), were isolated from the soft coral Sinularia grandilobata. Grandilobatin C (3) was found to have a novel skeleton with the C-4 methyl group of the normal cembranoid rearranged to C-3, while the other metabolites were identified as new 10-oxocembranoids. Metabolite 4 has weak cytotoxicity toward MDA-MB-23 human breast tumor cells. Also, 4 significantly inhibited the accumulation of the pro-inflammatory iNOS protein of LPS-stimulated RAW264.7 macrophage cells at 50 microM.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1520-6025
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
946-51
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pubmed:dateRevised |
2011-10-27
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pubmed:meshHeading |
pubmed-meshheading:18447385-Animals,
pubmed-meshheading:18447385-Anthozoa,
pubmed-meshheading:18447385-Anti-Inflammatory Agents,
pubmed-meshheading:18447385-Computer Simulation,
pubmed-meshheading:18447385-Diterpenes,
pubmed-meshheading:18447385-Drug Screening Assays, Antitumor,
pubmed-meshheading:18447385-Humans,
pubmed-meshheading:18447385-Lipopolysaccharides,
pubmed-meshheading:18447385-Macrophages,
pubmed-meshheading:18447385-Mice,
pubmed-meshheading:18447385-Molecular Structure,
pubmed-meshheading:18447385-Nitric Oxide Synthase Type II,
pubmed-meshheading:18447385-Taiwan
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pubmed:year |
2008
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pubmed:articleTitle |
A C-3 methylated isocembranoid and 10-oxocembranoids from a formosan soft coral, Sinularia grandilobata.
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pubmed:affiliation |
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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