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pubmed:abstractText |
Cerebral small vessel disease (SVD) appears on magnetic resonance imaging (MRI) as leukoaraiosis (LA), état criblé (EC), and multiple lacunar infarctions (MLI). Although the pathophysiology of SVD is poorly understood, there is evidence of a genetic contribution. We sought to analyze the influence of the renin-angiotensin-aldosterone system (RAAS) on SVD in symptomatic patients from the Génétique de l'Infarctus Cérébral (GENIC) study, including RAAS polymorphisms and circulating angiotensin converting enzyme (ACE).
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pubmed:affiliation |
INSERM-698 and Coordinating Centre for the GENIC study, Dept. of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Denis Diderot University, 46, rue Henri Huchard, 75018 Paris, France.
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