Source:http://linkedlifedata.com/resource/pubmed/id/18446263
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2008-7-3
|
| pubmed:abstractText |
The dopaminergic system has been shown to be involved in the aetiology of obsessive-compulsive disorder (OCD). Family studies suggest a higher genetic loading in patients with early onset OCD. Our investigation is the first family-based association study concerning polymorphisms in genes of the dopaminergic system in early onset OCD. We studied polymorphisms within the dopamine-4 receptor gene (DRD4), the dopamine transporter gene (DAT1) and the catecholamine-O-methyltransferase gene (COMT). Associations of alleles of DRD4 and COMT with OCD have previously been reported in adults, while a trend towards an association was found for DAT1 alleles. In our study we observed transmission disequilibrium for the 48-bp repeat polymorphism of the DRD4 gene using the ETDT (P=0.047) in 69 trios comprising patients with early onset OCD and both of their parents. Post hoc TDT analysis of the DRD4 showed reduced transmission of the 4-repeat allele and a slightly increased transmission rate for the 7- and the 2-repeat allele. No evidence of transmission disequilibrium was detected for alleles of the DAT1 and COMT polymorphisms. These polymorphisms do not appear to play a major role in the genetic predisposition to early onset OCD in our study group.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catechol O-Methyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D4,
http://linkedlifedata.com/resource/pubmed/chemical/SLC6A3 protein, human
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
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| pubmed:issn |
0300-9564
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| pubmed:author |
pubmed-author:GerlachManfredM,
pubmed-author:Herpertz-DahlmannBeateB,
pubmed-author:HinneyAnkeA,
pubmed-author:LangeKlaus WKW,
pubmed-author:RemschmidtHelmutH,
pubmed-author:RennerTobias JTJ,
pubmed-author:SchaferHelmutH,
pubmed-author:ScheragAndréA,
pubmed-author:SchulzEberhardE,
pubmed-author:WalitzaSusanneS,
pubmed-author:WewetzerChristophC
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| pubmed:issnType |
Print
|
| pubmed:volume |
115
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1071-8
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| pubmed:meshHeading |
pubmed-meshheading:18446263-Adolescent,
pubmed-meshheading:18446263-Catechol O-Methyltransferase,
pubmed-meshheading:18446263-Child,
pubmed-meshheading:18446263-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:18446263-Female,
pubmed-meshheading:18446263-Gene Frequency,
pubmed-meshheading:18446263-Genetic Predisposition to Disease,
pubmed-meshheading:18446263-Genotype,
pubmed-meshheading:18446263-Humans,
pubmed-meshheading:18446263-Linkage Disequilibrium,
pubmed-meshheading:18446263-Male,
pubmed-meshheading:18446263-Obsessive-Compulsive Disorder,
pubmed-meshheading:18446263-Polymorphism, Genetic,
pubmed-meshheading:18446263-Receptors, Dopamine D4
|
| pubmed:year |
2008
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| pubmed:articleTitle |
Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system.
|
| pubmed:affiliation |
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg, Füchsleinstr. 15, 97080 Würzburg, Germany. walitza@kjp.uni-wuerzburg.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|