Linked Life Data

18446212

Source:http://linkedlifedata.com/resource/pubmed/id/18446212

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-4-30
pubmed:abstractText
Mental or cognitive brain functions, and the effect on them of abnormal psychiatric diseases, are difficult to approach through molecular biological techniques due to the lack of appropriate assay systems with objective measures. We therefore study laws of behavioral organization, specifically how resting and active periods are interwoven throughout daily life, using objective criteria, and first discover that identical laws hold both for healthy humans subject to the full complexity of daily life, and wild-type mice subject to maximum environmental constraints. We find that active period durations with physical activity counts successively above a predefined threshold, when rescaled with individual means, follow a universal stretched exponential (gamma-type) cumulative distribution, while resting period durations below the threshold obey a universal power-law cumulative distribution with identical parameter values for both of the mammalian species. Further, by analyzing the behavioral organization of mice with a circadian clock gene (Period2) eliminated, and humans suffering from major depressive disorders, we find significantly lower parameter values (power-law scaling exponents) for the resting period durations in both these cases. Such a universality and breakdown of the behavioral organization of mice and humans, revealed through objective measures, is expected to facilitate the understanding of the molecular basis of the pathophysiology of neurobehavioral diseases, including depression, and lay the foundations for formulating a range of neuropsychiatric behavioral disorder models.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-10408444, http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-14657176, http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-15089251, http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-15175392, http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-15889093, http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-16049932, http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-16384430, http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-17275102, http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-17469191, http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-17930642, http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-2862799, http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-3421804, http://linkedlifedata.com/resource/pubmed/commentcorrection/18446212-3864177
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1932-6203
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e2050
pubmed:dateRevised
2010-9-22
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Of mice and men--universality and breakdown of behavioral organization.
pubmed:affiliation
The Center for Advanced Medical Engineering and Informatics, Osaka University, Osaka, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't