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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-4-30
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pubmed:abstractText |
Simple biomarkers are required to identify TB in both HIV(-)TB(+) and HIV(+)TB(+) patients. Earlier studies have identified the M. tuberculosis Malate Synthase (MS) and MPT51 as immunodominant antigens in TB patients. One goal of these investigations was to evaluate the sensitivity and specificity of anti-MS and -MPT51 antibodies as biomarkers for TB in HIV(-)TB(+) and HIV(+)TB(+) patients from a TB-endemic setting. Earlier studies also demonstrated the presence of these biomarkers during incipient subclinical TB. If these biomarkers correlate with incipient TB, their prevalence should be higher in asymptomatic HIV(+) subjects who are at a high-risk for TB. The second goal was to compare the prevalence of these biomarkers in asymptomatic, CD4(+) T cell-matched HIV(+)TB(-) subjects from India who are at high-risk for TB with similar subjects from US who are at low-risk for TB.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e2071
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18446210-Antibodies, Bacterial,
pubmed-meshheading:18446210-Antigens, Bacterial,
pubmed-meshheading:18446210-Bacterial Proteins,
pubmed-meshheading:18446210-Biological Markers,
pubmed-meshheading:18446210-Case-Control Studies,
pubmed-meshheading:18446210-Endemic Diseases,
pubmed-meshheading:18446210-HIV Seropositivity,
pubmed-meshheading:18446210-Humans,
pubmed-meshheading:18446210-India,
pubmed-meshheading:18446210-Malate Synthase,
pubmed-meshheading:18446210-Mycobacterium tuberculosis,
pubmed-meshheading:18446210-Risk Factors,
pubmed-meshheading:18446210-Tuberculin,
pubmed-meshheading:18446210-Tuberculosis
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pubmed:year |
2008
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pubmed:articleTitle |
Biomarkers for clinical and incipient tuberculosis: performance in a TB-endemic country.
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pubmed:affiliation |
Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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