Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-6-25
pubmed:abstractText
The association between trimethoprim-sulfamethoxazole use and resistance among the major respiratory tract pathogens was investigated by comparing regional consumption of the drug to regional resistance in the following year in 21 central hospital districts in Finland. A total of 23,530 Streptococcus pneumoniae isolates, 28,320 Haemophilus influenzae isolates, and 14,138 Moraxella catarrhalis isolates were tested for trimethoprim-sulfamethoxazole susceptibility during the study period (1998-2004). Among the S. pneumoniae isolates, a statistically significant connection was found between regional consumption and resistance. No statistically significant connection was found between regional trimethoprim-sulfamethoxazole use and resistance among H. influenzae and M. catarrhalis isolates. According to our results, it seems that only in pneumococci can the development of trimethoprim-sulfamethoxazole resistance be influenced by restricting its use. However, trimethoprim-sulfamethoxazole remains an important antimicrobial agent because of its reasonable price. Hence, resistance to trimethoprim-sulfamethoxazole among these pathogens needs continuous monitoring.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-10747822, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-11266425, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-11320449, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-11340533, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-11462184, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-12149359, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-12363007, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-12556431, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-12672574, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-14613955, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-15127336, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-15156452, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-1589657, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-15983908, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-16150859, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-17606677, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-3524425, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-7726483, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-8589142, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-8897179, http://linkedlifedata.com/resource/pubmed/commentcorrection/18443116-9250845
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1098-6596
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2480-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Connection between trimethoprim-sulfamethoxazole use and resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.
pubmed:affiliation
Päijät-Häme Social and Health Care Group, Clinical Microbiology, Keskussairaalankatu 7, SF-15850 Lahti, Finland. pauliina.karpanoja@phsotey.fi
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't