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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2008-6-10
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pubmed:abstractText |
A subset of patients with diffuse gastric cancer harbor deleterious cancer-causing germline mutations in the type 1 E-cadherin (epithelial) gene (CDH1), which predisposes to the autosomal dominantly inherited hereditary diffuse gastric cancer (HDGC) syndrome. These mutations are associated with a 70% life-time risk for diffuse gastric cancer (DGC) and an additional 40% risk for lobular breast cancer in women. Management options for unaffected mutation carriers include prophylactic total gastrectomy.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-10433926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-10593993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-10969494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-11104024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-11241226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-12588804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-12647996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-12810455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-14320675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-15235021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-15895459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-16061854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-16489633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-16801346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-17522512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-17545690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-17634464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18442100-9537325
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2008 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2655-63
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pubmed:dateRevised |
2011-5-4
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pubmed:meshHeading |
pubmed-meshheading:18442100-Adult,
pubmed-meshheading:18442100-Aged,
pubmed-meshheading:18442100-Cadherins,
pubmed-meshheading:18442100-Cohort Studies,
pubmed-meshheading:18442100-Female,
pubmed-meshheading:18442100-Gastrectomy,
pubmed-meshheading:18442100-Genetic Counseling,
pubmed-meshheading:18442100-Heterozygote,
pubmed-meshheading:18442100-Humans,
pubmed-meshheading:18442100-Male,
pubmed-meshheading:18442100-Middle Aged,
pubmed-meshheading:18442100-Mutation,
pubmed-meshheading:18442100-Pedigree,
pubmed-meshheading:18442100-Stomach Neoplasms
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pubmed:year |
2008
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pubmed:articleTitle |
Hereditary diffuse gastric cancer: diagnosis, genetic counseling, and prophylactic total gastrectomy.
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pubmed:affiliation |
Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska 68178, USA. htlynch@creighton.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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