pubmed:abstractText |
We investigated, in three beta cell lines (INS-1E, RIN-5AH, betaTC3) and in human and rodent primary beta cells, the storage and release of chromogranin B, a secretory protein expressed in beta cells and postulated to play an autocrine role. We asked whether chromogranin B is stored together with and discharged in constant ratio to insulin upon various stimuli.
|
pubmed:affiliation |
Immunology of Diabetes Research Unit, San Raffaele Scientific Institute, Via Olgettina, 60, 20132 Milan, Italy.
|