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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-4-25
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pubmed:abstractText |
The mitochondrial permeability transition (MPT) pore may serve as the end-effector of cardioprotective mechanisms, namely the mitochondrial K(ATP) channels and glycogen synthase kinase-3beta (GSK-3beta). We recently showed that augmented MPT pore induction contributes to pressure overload-induced exacerbation of infarct size. This study tests the hypotheses that (i) elevation in perfusion pressure attenuates cardioprotection associated with activation of mitochondrial KATP channels or inhibition of GSK-3beta and (ii) perfusion pressure modulates the regulation of the MPT pore by mitochondrial KATP channels and/or GSK-3beta.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cardiotonic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Diazoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Glyburide,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Maleimides,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/SB 216763,
http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial K(ATP) channel,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial permeability...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0895-7061
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
570-5
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:18437149-Animals,
pubmed-meshheading:18437149-Cardiotonic Agents,
pubmed-meshheading:18437149-Cyclosporine,
pubmed-meshheading:18437149-Diazoxide,
pubmed-meshheading:18437149-Disease Models, Animal,
pubmed-meshheading:18437149-Glyburide,
pubmed-meshheading:18437149-Glycogen Synthase Kinase 3,
pubmed-meshheading:18437149-Hypertension,
pubmed-meshheading:18437149-Indoles,
pubmed-meshheading:18437149-Lithium Chloride,
pubmed-meshheading:18437149-Male,
pubmed-meshheading:18437149-Maleimides,
pubmed-meshheading:18437149-Mitochondria, Heart,
pubmed-meshheading:18437149-Mitochondrial Membrane Transport Proteins,
pubmed-meshheading:18437149-Myocardial Infarction,
pubmed-meshheading:18437149-Myocardial Reperfusion Injury,
pubmed-meshheading:18437149-Myocardium,
pubmed-meshheading:18437149-Perfusion,
pubmed-meshheading:18437149-Potassium Channel Blockers,
pubmed-meshheading:18437149-Potassium Channels,
pubmed-meshheading:18437149-Protein Kinase Inhibitors,
pubmed-meshheading:18437149-Rats,
pubmed-meshheading:18437149-Rats, Sprague-Dawley,
pubmed-meshheading:18437149-Ventricular Function, Left,
pubmed-meshheading:18437149-Ventricular Pressure
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pubmed:year |
2008
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pubmed:articleTitle |
Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore.
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pubmed:affiliation |
Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia, USA. Mmozaffa@mail.mcg.edu
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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