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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-6-24
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pubmed:abstractText |
Severe cerebral edema is associated with poor outcome in patients with acute stroke. Experimental studies suggest that astrocytic endothelin-1 (ET-1) has deleterious effects on water homeostasis, cerebral edema, and blood brain barrier (BBB) integrity, which contribute to more severe ischemic brain injury. In this study we analyze the association between high serum levels of ET-1 and the development of severe cerebral edema in patients treated with t-PA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2006-10
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pubmed:meshHeading |
pubmed-meshheading:18436890-Aged,
pubmed-meshheading:18436890-Brain Edema,
pubmed-meshheading:18436890-Brain Ischemia,
pubmed-meshheading:18436890-Endothelin-1,
pubmed-meshheading:18436890-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18436890-Female,
pubmed-meshheading:18436890-Fibronectins,
pubmed-meshheading:18436890-Humans,
pubmed-meshheading:18436890-Male,
pubmed-meshheading:18436890-Matrix Metalloproteinase 9,
pubmed-meshheading:18436890-Middle Aged,
pubmed-meshheading:18436890-Odds Ratio,
pubmed-meshheading:18436890-Stroke,
pubmed-meshheading:18436890-Thrombolytic Therapy,
pubmed-meshheading:18436890-Tissue Plasminogen Activator
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pubmed:year |
2008
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pubmed:articleTitle |
High serum levels of endothelin-1 predict severe cerebral edema in patients with acute ischemic stroke treated with t-PA.
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pubmed:affiliation |
Department of Neurology, Clinical Neuroscience Research Laboratory, Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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