Linked Life Data

18435932

Source:http://linkedlifedata.com/resource/pubmed/id/18435932

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-6-13
pubmed:abstractText
Clostridium difficile toxins A and B are major virulence factors implicated in pseudomembranous colitis and antibiotic-associated diarrhea. The toxins are glucosyltransferases, which inactivate Rho proteins involved in cellular signaling. Human alpha-defensins as part of the innate immune system inactivate various microbial pathogens as well as specific bacterial exotoxins. Here, we studied the effects of alpha-defensins human neutrophil protein (HNP)-1, HNP-3, and enteric human defensin (HD)-5 on the activity of C difficile toxins A and B.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents, http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins, http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/alpha-Defensins, http://linkedlifedata.com/resource/pubmed/chemical/alpha-defensin 5, human, http://linkedlifedata.com/resource/pubmed/chemical/cdc42 GTP-Binding Protein, http://linkedlifedata.com/resource/pubmed/chemical/human neutrophil peptide 1, http://linkedlifedata.com/resource/pubmed/chemical/human neutrophil peptide 3, http://linkedlifedata.com/resource/pubmed/chemical/rac1 GTP-Binding Protein, http://linkedlifedata.com/resource/pubmed/chemical/rhoA GTP-Binding Protein, http://linkedlifedata.com/resource/pubmed/chemical/tcdA protein, Clostridium difficile, http://linkedlifedata.com/resource/pubmed/chemical/toxB protein, Clostridium difficile
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1528-0012
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2049-58
pubmed:meshHeading
pubmed-meshheading:18435932-Animals, pubmed-meshheading:18435932-Anti-Infective Agents, pubmed-meshheading:18435932-Bacterial Proteins, pubmed-meshheading:18435932-Bacterial Toxins, pubmed-meshheading:18435932-Caco-2 Cells, pubmed-meshheading:18435932-Cell Survival, pubmed-meshheading:18435932-Dose-Response Relationship, Drug, pubmed-meshheading:18435932-Electric Impedance, pubmed-meshheading:18435932-Enterotoxins, pubmed-meshheading:18435932-Enzyme Inhibitors, pubmed-meshheading:18435932-Glycosylation, pubmed-meshheading:18435932-Humans, pubmed-meshheading:18435932-Intestinal Mucosa, pubmed-meshheading:18435932-Mice, pubmed-meshheading:18435932-Protein Binding, pubmed-meshheading:18435932-Swiss 3T3 Cells, pubmed-meshheading:18435932-Time Factors, pubmed-meshheading:18435932-alpha-Defensins, pubmed-meshheading:18435932-cdc42 GTP-Binding Protein, pubmed-meshheading:18435932-rac1 GTP-Binding Protein, pubmed-meshheading:18435932-rhoA GTP-Binding Protein
pubmed:year
2008
pubmed:articleTitle
Human alpha-defensins inhibit Clostridium difficile toxin B.
pubmed:affiliation
Institut für Experimentelle and Klinische Pharmakologie und Toxikologie, Universität Freiburg, Freiburg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't