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pubmed:abstractText |
Amplification of the TNK2 gene in primary tumours correlates with poor prognosis. In accordance, TNK2 overexpression was shown to promote invasion of cancer cells--but the mechanism by which TNK2 mediates these effects is unresolved. TNK2 was suggested to regulate Cdc42-driven migration by activation of breast cancer antioestrogen resistance 1 (BCAR1); however, distinct from this effect is evidence for a role of TNK2 in the regulation of epidermal growth factor receptor (EGFR) endocytosis and degradation. In the present study we sought to investigate whether negative targeting of TNK2 by siRNA could be used to inhibit cancer cell invasion, to establish the contribution of its effect on the EGFR and to consequently attempt to resolve the issue of TNK2's mechanism of action.
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pubmed:affiliation |
Cell and Experimental Pathology, Lund University, Department of Laboratory Medicine, Clinical Research Centre, Ent 72, Bldg 91, fl 11, Malmö University Hospital, S-205 02 Malmö, Sweden. jillian.howlin@med.lu.se
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