Linked Life Data

18435686

Source:http://linkedlifedata.com/resource/pubmed/id/18435686

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-7-9
pubmed:abstractText
The long term goal of immunological therapy for transplantation is to induce antigen specific unresponsiveness. One approach of significant current interest is the induction of T regulatory (Treg) cells that downregulate immune responses in an antigen specific manner. In this study, we examined the nature of the immunological regulation initiated by oral exposure to alloantigen. We previously demonstrated that feeding of allogeneic donor splenocytes significantly prolongs kidney allograft survival in rats. Purified CD8+ graft infiltrating cells (GIC), but not CD4+ GIC transfer graft prolongation to naïve animals demonstrating the presence of a CD8+ Treg population in the graft. In this study, we provide evidence that is consistent with a hypothesis that the CD8+ Treg generated by oral exposure to alloantigen is an IL-10 secreting, gammadelta TCR+ T cell.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0934-0874
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
679-87
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
CD8+ gammadelta T regulatory cells mediate kidney allograft prolongation after oral exposure to alloantigen.
pubmed:affiliation
Department of Microbiology & Immunology, Dalhousie University, Halifax, NS, Canada. juanzj@dal.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't