| pubmed-article:18434611 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C0939930 | lld:lifeskim |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C1122976 | lld:lifeskim |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C0023434 | lld:lifeskim |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C0876956 | lld:lifeskim |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C1539721 | lld:lifeskim |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C1539386 | lld:lifeskim |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18434611 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18434611 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18434611 | pubmed:dateCreated | 2008-7-8 | lld:pubmed |
| pubmed-article:18434611 | pubmed:abstractText | To identify novel genes involved in the molecular pathogenesis of chronic lymphocytic leukemia (CLL) we performed a serial analysis of gene expression (SAGE) in CLL cells, and compared this with healthy B cells (nCD19(+)). We found a high level of similarity among CLL subtypes, but a comparison of CLL versus nCD19(+) libraries revealed 55 genes that were over-represented and 49 genes that were down-regulated in CLL. A gene ontology analysis revealed that TOSO, which plays a functional role upstream of Fas extrinsic apoptosis pathway, was over-expressed in CLL cells. This finding was confirmed by real-time reverse transcription-polymerase chain reaction in 78 CLL and 12 nCD19(+) cases (P < .001). We validated expression using flow cytometry and tissue microarray and demonstrated a 5.6-fold increase of TOSO protein in circulating CLL cells (P = .013) and lymph nodes (P = .006). Our SAGE results have demonstrated that TOSO is a novel over-expressed antiapoptotic gene in CLL. | lld:pubmed |
| pubmed-article:18434611 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18434611 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:18434611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434611 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18434611 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:18434611 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:18434611 | pubmed:author | pubmed-author:MorrisKellyK | lld:pubmed |
| pubmed-article:18434611 | pubmed:author | pubmed-author:GribbenJohn... | lld:pubmed |
| pubmed-article:18434611 | pubmed:author | pubmed-author:OwenCarolynC | lld:pubmed |
| pubmed-article:18434611 | pubmed:author | pubmed-author:ZagoMarco AMA | lld:pubmed |
| pubmed-article:18434611 | pubmed:author | pubmed-author:SilvaWilson... | lld:pubmed |
| pubmed-article:18434611 | pubmed:author | pubmed-author:FalcãoRoberto... | lld:pubmed |
| pubmed-article:18434611 | pubmed:author | pubmed-author:RizzattiEdgar... | lld:pubmed |
| pubmed-article:18434611 | pubmed:author | pubmed-author:Proto-Siqueir... | lld:pubmed |
| pubmed-article:18434611 | pubmed:author | pubmed-author:PanepucciRodr... | lld:pubmed |
| pubmed-article:18434611 | pubmed:author | pubmed-author:LeeAbigailA | lld:pubmed |
| pubmed-article:18434611 | pubmed:author | pubmed-author:CaretaFrancis... | lld:pubmed |
| pubmed-article:18434611 | pubmed:author | pubmed-author:ClearAndrewA | lld:pubmed |
| pubmed-article:18434611 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18434611 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18434611 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:18434611 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18434611 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18434611 | pubmed:pagination | 394-7 | lld:pubmed |
| pubmed-article:18434611 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18434611 | pubmed:meshHeading | pubmed-meshheading:18434611... | lld:pubmed |
| pubmed-article:18434611 | pubmed:meshHeading | pubmed-meshheading:18434611... | lld:pubmed |
| pubmed-article:18434611 | pubmed:meshHeading | pubmed-meshheading:18434611... | lld:pubmed |
| pubmed-article:18434611 | pubmed:meshHeading | pubmed-meshheading:18434611... | lld:pubmed |
| pubmed-article:18434611 | pubmed:meshHeading | pubmed-meshheading:18434611... | lld:pubmed |
| pubmed-article:18434611 | pubmed:meshHeading | pubmed-meshheading:18434611... | lld:pubmed |
| pubmed-article:18434611 | pubmed:meshHeading | pubmed-meshheading:18434611... | lld:pubmed |
| pubmed-article:18434611 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18434611 | pubmed:articleTitle | SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL. | lld:pubmed |
| pubmed-article:18434611 | pubmed:affiliation | Hematology Division and Center for Cell-Based Therapy, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil. | lld:pubmed |
| pubmed-article:18434611 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18434611 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18434611 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:9214 | entrezgene:pubmed | pubmed-article:18434611 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18434611 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18434611 | lld:pubmed |
