| pubmed-article:18434325 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18434325 | lifeskim:mentions | umls-concept:C0384648 | lld:lifeskim |
| pubmed-article:18434325 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:18434325 | lifeskim:mentions | umls-concept:C1416467 | lld:lifeskim |
| pubmed-article:18434325 | lifeskim:mentions | umls-concept:C1825592 | lld:lifeskim |
| pubmed-article:18434325 | lifeskim:mentions | umls-concept:C1705947 | lld:lifeskim |
| pubmed-article:18434325 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:18434325 | lifeskim:mentions | umls-concept:C1158816 | lld:lifeskim |
| pubmed-article:18434325 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:18434325 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:18434325 | lifeskim:mentions | umls-concept:C2717992 | lld:lifeskim |
| pubmed-article:18434325 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:18434325 | pubmed:dateCreated | 2008-6-16 | lld:pubmed |
| pubmed-article:18434325 | pubmed:abstractText | The cytokine, transforming growth factor-beta1 (TGF-beta1), converts naive T cells into regulatory T cells that prevent autoimmunity. However, in the presence of interleukin (IL)-6, TGF-beta1 has also been found to promote differentiation into IL-17-producing helper T (Th17) cells that are deeply involved in autoimmunity and inflammation. However, it has not been clarified how TGF-beta1 and IL-6 determine such a distinct fate. Here we found that a master regulator for Th17, retinoic acid-related orphan receptor gammat (RORgammat), was rapidly induced by TGF-beta1 regardless of the presence of IL-6. IL-6 reduced Foxp3 expression, and overexpression of Foxp3 in a T cell line resulted in a strong reduction of IL-17A expression. We have characterized the IL-17A promoter and found that RORgammat binding is sufficient for activation of the minimum promoter in the HEK 293T cells. RORgammat-mediated IL-17A promoter activation was suppressed by forced expression of Foxp3. Foxp3 directly interacted with RORgammat through exon 2 region of Foxp3. The exon 2 region and forkhead (FKH) domain of Foxp3 were necessary for the suppression of RORgammat-mediated IL-17A promoter activation. We propose that induction of Foxp3 is the mechanism for the suppression of Th17 and polarization into inducible Treg. | lld:pubmed |
| pubmed-article:18434325 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18434325 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18434325 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18434325 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18434325 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18434325 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18434325 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:18434325 | pubmed:author | pubmed-author:KobayashiTaka... | lld:pubmed |
| pubmed-article:18434325 | pubmed:author | pubmed-author:TakaesuGiichi... | lld:pubmed |
| pubmed-article:18434325 | pubmed:author | pubmed-author:YoshidaHideyu... | lld:pubmed |
| pubmed-article:18434325 | pubmed:author | pubmed-author:YoshimuraAkih... | lld:pubmed |
| pubmed-article:18434325 | pubmed:author | pubmed-author:HoriShoheiS | lld:pubmed |
| pubmed-article:18434325 | pubmed:author | pubmed-author:ChinenTakatos... | lld:pubmed |
| pubmed-article:18434325 | pubmed:author | pubmed-author:SaekiKazukoK | lld:pubmed |
| pubmed-article:18434325 | pubmed:author | pubmed-author:NakayaMakoM | lld:pubmed |
| pubmed-article:18434325 | pubmed:author | pubmed-author:IchiyamaKenji... | lld:pubmed |
| pubmed-article:18434325 | pubmed:author | pubmed-author:WakabayashiYu... | lld:pubmed |
| pubmed-article:18434325 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18434325 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:18434325 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:18434325 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18434325 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18434325 | pubmed:pagination | 17003-8 | lld:pubmed |
| pubmed-article:18434325 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:18434325 | pubmed:meshHeading | pubmed-meshheading:18434325... | lld:pubmed |
| pubmed-article:18434325 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18434325 | pubmed:articleTitle | Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. | lld:pubmed |
| pubmed-article:18434325 | pubmed:affiliation | Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. | lld:pubmed |
| pubmed-article:18434325 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18434325 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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