Linked Life Data

18433754

Source:http://linkedlifedata.com/resource/pubmed/id/18433754

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-10-30
pubmed:abstractText
Inflammation in atherosclerotic plaques makes them unstable and can cause thrombosis. Therefore, it is important to detect macrophage activity for clinical management of atherosclerosis. Peripheral benzodiazepine receptor (PBR) is expressed in various tissue and organs including macrophages. In this study, we tested whether inflammation characterized by macrophage infiltration can be detected by PBR binding. Six patients diagnosed as carotid atherosclerosis underwent endarterectomy. Using the fresh frozen sections, presence of PBRs and macrophages was examined by in vitro autoradiography using [(3)H]PK 11195 and immunohistochemical staining of CD68, respectively. All sections showed specific binding of [(3)H]PK 11195, and the staining with CD68 indicating macrophage infiltration. Density and distribution of PBR detected by [(3)H]PK 11195 autoradiography were consistent with those of the immunohistochemical staining. In conclusion, this study demonstrated that macrophage and inflammatory activity in atherosclerotic plaque can be imaged specifically by the binding of PBR indicating future application of PET imaging for PBR.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1879-1484
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
201
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
108-11
pubmed:meshHeading
pubmed-meshheading:18433754-Aged, pubmed-meshheading:18433754-Aged, 80 and over, pubmed-meshheading:18433754-Antigens, CD, pubmed-meshheading:18433754-Antigens, Differentiation, Myelomonocytic, pubmed-meshheading:18433754-Antineoplastic Agents, pubmed-meshheading:18433754-Atherosclerosis, pubmed-meshheading:18433754-Autoradiography, pubmed-meshheading:18433754-Carotid Artery Diseases, pubmed-meshheading:18433754-Cohort Studies, pubmed-meshheading:18433754-Endarterectomy, pubmed-meshheading:18433754-Feasibility Studies, pubmed-meshheading:18433754-Female, pubmed-meshheading:18433754-Humans, pubmed-meshheading:18433754-Isoquinolines, pubmed-meshheading:18433754-Macrophages, pubmed-meshheading:18433754-Male, pubmed-meshheading:18433754-Neutrophil Infiltration, pubmed-meshheading:18433754-Receptors, GABA-A
pubmed:year
2008
pubmed:articleTitle
Increased peripheral benzodiazepine receptors in arterial plaque of patients with atherosclerosis: an autoradiographic study with [(3)H]PK 11195.
pubmed:affiliation
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA. fujimuray@mail.nih.gov
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural