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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-4-24
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pubmed:abstractText |
Nitric oxide (NO*) is a critical component of mammalian host defense that is produced in macrophages and other cells comprising the innate immune system. Isolated mammalian macrophages have been utilized to measure the kinetics of NO production and to demonstrate NO-related antimicrobial actions. Some microorganisms possess enzymes to detoxify nitrogen oxides, and mutant strains lacking these enzymes can be used to demonstrate the importance of these mechanisms for intracellular bacterial survival. This chapter describes techniques with which to analyze the antimicrobial actions of nitric oxide in murine and human macrophages and in laboratory mice.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18433645-10023768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18433645-10377158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18433645-10899909,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18433645-16873371,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18433645-9848075
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0076-6879
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
437
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
521-38
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:18433645-Animals,
pubmed-meshheading:18433645-Anti-Infective Agents,
pubmed-meshheading:18433645-Humans,
pubmed-meshheading:18433645-Macrophage Activation,
pubmed-meshheading:18433645-Macrophages,
pubmed-meshheading:18433645-Mice,
pubmed-meshheading:18433645-Mice, Knockout,
pubmed-meshheading:18433645-Microbial Sensitivity Tests,
pubmed-meshheading:18433645-Microbial Viability,
pubmed-meshheading:18433645-Nitric Oxide,
pubmed-meshheading:18433645-Nitric Oxide Synthase Type II,
pubmed-meshheading:18433645-Salmonella Infections, Animal,
pubmed-meshheading:18433645-Salmonella enterica
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pubmed:year |
2008
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pubmed:articleTitle |
Analysis of nitric oxide-dependent antimicrobial actions in macrophages and mice.
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pubmed:affiliation |
University of Colorado Health Sciences Center, Aurora, Colorado, USA.
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pubmed:publicationType |
Journal Article,
Review
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