Linked Life Data

18431565

Source:http://linkedlifedata.com/resource/pubmed/id/18431565

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-6-18
pubmed:abstractText
Previous studies have indicated that interleukin-1 beta (IL-1 beta) is involved not only in immune modulation, but also in the modulation of pain in both the peripheral and central nervous systems. The current study investigated the expression of IL-1 beta in the brain of rats with spared nerve injury (SNI), using immunohistochemical technique. The results showed that immunoreactive-like IL-1 beta protein was significantly elevated in the Red nucleus (RN) 2 weeks after SNI. To further study the function of IL-1 beta in RN, different doses of IL-1 beta neutralizing antibody (10, 1.0 and 0.1 ng) were microinjected into the RN contralateral to the nerve injury side of neuropathic rats. The results indicated that the higher doses of anti-IL-1 beta antibody (10 and 1.0 ng) significantly attenuated the mechanical allodynia of neuropathic rats. However, administration of 0.1 ng anti-IL-1 beta antibody did not show anti-allodynia effect. These results suggest that IL-1 beta of RN is involved in the development of neuropathic pain in SNI rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1432-1106
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
188
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
379-84
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Interleukin-1 beta of Red nucleus involved in the development of allodynia in spared nerve injury rats.
pubmed:affiliation
Department of Immunology and Pathogenic Biology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, 710061, People's Republic of China.
pubmed:publicationType
Journal Article