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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-4-22
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pubmed:abstractText |
Hypospadias is a common inborn error of the genital development, whose complex etiology remains elusive. Defects of the androgen metabolism and activity have been found in a subset of boys with hypospadias. Moreover, the balance between androgens and estrogens seems to be important to the proper male genital development. Activating transcription factor 3 (ATF3), an estrogen responsive gene, has been reported to be expressed during sexual development and up-regulated in hypospadic genital skin. We investigated ATF3 as a candidate gene for hypospadias.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1479-683X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
729-39
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pubmed:meshHeading |
pubmed-meshheading:18426833-Activating Transcription Factor 3,
pubmed-meshheading:18426833-Base Sequence,
pubmed-meshheading:18426833-Child,
pubmed-meshheading:18426833-DNA Mutational Analysis,
pubmed-meshheading:18426833-Female,
pubmed-meshheading:18426833-Fetus,
pubmed-meshheading:18426833-Genetic Predisposition to Disease,
pubmed-meshheading:18426833-Genitalia, Female,
pubmed-meshheading:18426833-Genitalia, Male,
pubmed-meshheading:18426833-Haplotypes,
pubmed-meshheading:18426833-Humans,
pubmed-meshheading:18426833-Hypospadias,
pubmed-meshheading:18426833-Immunohistochemistry,
pubmed-meshheading:18426833-Introns,
pubmed-meshheading:18426833-Logistic Models,
pubmed-meshheading:18426833-Male,
pubmed-meshheading:18426833-Molecular Sequence Data,
pubmed-meshheading:18426833-Polymorphism, Single Nucleotide,
pubmed-meshheading:18426833-Protein Structure, Quaternary,
pubmed-meshheading:18426833-Risk Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Activating transcription factor 3: a hormone responsive gene in the etiology of hypospadias.
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pubmed:affiliation |
Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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