Linked Life Data

18426658

Source:http://linkedlifedata.com/resource/pubmed/id/18426658

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-4-22
pubmed:abstractText
The aim of this study was to investigate whether the single nucleotide polymorphism (SNP) of interferon-gamma (IFN-gamma) +874 T/A correlates with aplastic anemia. Amplification refractory mutation system-polymerase chain reaction was used to amplify the polymorphism gene segment of IFN-gamma +874 A/T from 54 aplastic anemia patients and 51 healthy adults. The results showed that the frequency of IFN-gamma +874 TT genotype and T allele was significantly higher in patients with aplastic anemia than that in the healthy adults (42.6% vs 17.6%, chi2=13.780, p=0.01; 65.7% vs 39.2%; chi2=14.811, p<0.001). In conclusion, IFN-gamma +874 A/T gene polymorphism is correlated with the susceptibility of aplastic anemia, but not significantly correlated with the the severity of aplastic anemia.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1009-2137
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
[Single nucleotide polymorphism of interferon-gamma gene +874 T/A in patients with aplastic anemia].
pubmed:affiliation
Department of Hematology, Laboratory of Blood Genetics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. changhonghx@163.com
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't