Linked Life Data

18424840

Source:http://linkedlifedata.com/resource/pubmed/id/18424840

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-4-21
pubmed:abstractText
Congenital cystic adenomatoid malformation (CCAM) is a developmental lung abnormality characterized by abnormal proliferation of mesenchymal elements and failure of bronchiolar structures to mature, ultimately resulting in the compression of normal pulmonary tissue and mediastinal shift with rapid expansion of cysts. Although various clinical and pathologic studies of CCAM in humans exist, CCAM has yet to be reported in animals, even in nonhuman primates. In the present study, histopathologic analyses of a neonatal cynomolgus monkey that died 17 days after birth revealed that normal lung architecture was replaced by disorganized overgrowths of cysts lined with simple cuboidal epithelium. The epithelium projected a few ciliates into the air spaces and produced mucus. To our knowledge, this is the first case study describing CCAM or a CCAM-like lesion in nonhuman primates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0300-9858
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
232-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Congenital cystic adenomatoid-like malformation in a cynomolgus monkey (Macaca fascicularis).
pubmed:affiliation
The Corporation for Production and Research of Laboratory Primates, Hachimandai 1-1, Tsukuba-shi, Ibaraki, Japan. okarin@primate.or.jp
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't