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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-4-21
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pubmed:abstractText |
Chronic lymphocytic leukemia (CLL) is characterized by a highly variable clinical course. The role of an autologous tumor-specific immune control contributing to the variable length of survival in CLL is poorly understood. We investigated whether humoral immunity specific for the CLL-associated Ag oncofetal Ag/immature laminin receptor (OFA/iLR) has a prognostic value in CLL. Among sera of 67 untreated patients with CLL, 23 (34.3%) had detectable OFA/iLR Abs that were reactive for at least one specific OFA/iLR epitope. Patients with humoral responses compared with patients with nonreactive sera had a longer progression-free survival (p = 0.029). IgG subclass analyses showed a predominant IgG1 and IgG3 response. OFA/iLR Abs were capable of recognizing and selectively killing OFA/iLR-expressing CLL cells in complement-mediated and Ab-dependent cellular cytotoxicity assays. In the analysis of 11 CLL patients after allogeneic hematopoietic stem cell transplantation, 8 showed high values for OFA/iLR Abs that specifically recognized the extracellular domain of the protein, suggesting a potential role of anti-OFA/iLR-directed immune responses to the graft-vs-leukemia effect in CLL. Our data suggest that spontaneous tumor-specific humoral immune responses against OFA/iLR exist in a significant proportion of CLL patients and that superior progression-free survival in those patients could reflect autologous immune control.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/RPSA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/oncofetal antigens
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:BarsoumAdelA,
pubmed-author:CogginJosephJJr,
pubmed-author:FriedrichsBirteB,
pubmed-author:HeidornKlausK,
pubmed-author:JakobIljaI,
pubmed-author:KabelitzDieterD,
pubmed-author:KloessMaritaM,
pubmed-author:RohrerJamesJ,
pubmed-author:SchmitzNorbertN,
pubmed-author:SchulteChristophC,
pubmed-author:SiegelSandraS,
pubmed-author:SteinmannJörgJ,
pubmed-author:TiemannMarkusM,
pubmed-author:ZeisMatthiasM
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6374-84
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pubmed:meshHeading |
pubmed-meshheading:18424761-Adult,
pubmed-meshheading:18424761-Aged,
pubmed-meshheading:18424761-Aged, 80 and over,
pubmed-meshheading:18424761-Antibodies, Neoplasm,
pubmed-meshheading:18424761-Antibody Formation,
pubmed-meshheading:18424761-Antibody Specificity,
pubmed-meshheading:18424761-Antigens, Neoplasm,
pubmed-meshheading:18424761-Disease-Free Survival,
pubmed-meshheading:18424761-Female,
pubmed-meshheading:18424761-Graft vs Leukemia Effect,
pubmed-meshheading:18424761-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:18424761-Humans,
pubmed-meshheading:18424761-Immunoglobulin G,
pubmed-meshheading:18424761-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:18424761-Male,
pubmed-meshheading:18424761-Middle Aged,
pubmed-meshheading:18424761-Receptors, Laminin,
pubmed-meshheading:18424761-Ribosomal Proteins,
pubmed-meshheading:18424761-Survival Rate,
pubmed-meshheading:18424761-Transplantation, Homologous
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pubmed:year |
2008
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pubmed:articleTitle |
Humoral immune responses against the immature laminin receptor protein show prognostic significance in patients with chronic lymphocytic leukemia.
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pubmed:affiliation |
Department of Hematology and Stem Cell Transplantation, Asklepios Hospital St. Georg, Lohmühlenstrasse 5, Hamburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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