Linked Life Data

18424335

Source:http://linkedlifedata.com/resource/pubmed/id/18424335

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-4-21
pubmed:abstractText
The past several years have brought an increased awareness of the prevalence of autoimmunity and immune dysregulation among patients who have primary immunodeficiency disorders (PIDD). The recent clinical and molecular definition of PIDD, in which the primary defect is in the immunoregulatory compartment of the immune system, has offered insight into the basic mechanisms of immune tolerance, which has provided new targets and new techniques to study immune tolerance in PIDD. Many of these studies have focused on the presence and function of regulatory T (T(REG)) cells in PIDD, particularly since the discovery of murine and human syndromes associated with T(REG) deficiency. This article focuses on the current state of knowledge regarding the role of T(REG) in various PIDD that have clinical features indicative of dysregulated immunity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0889-8561
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
315-27, viii-ix
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Immune dysregulation in primary immunodeficiency disorders.
pubmed:affiliation
Divisions of Pediatric Immunology and Rheumatology, University of Washington School of Medicine and Children's Hospital Regional Medical Center, Seattle, WA 98109, USA. troy.torgerson@seattlechildrens.org
pubmed:publicationType
Journal Article, Review