Linked Life Data

1842347

Source:http://linkedlifedata.com/resource/pubmed/id/1842347

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-1-7
pubmed:abstractText
Serum osteocalcin (OC), which is a specific, sensitive, and rapidly responding biochemical bone marker of osteoblastic activity, varies in a circadian rhythm in both normal adults and children with the highest levels during nighttime. In the present study, we characterized the 24-h rhythm of serum OC in 8 growth hormone (GH)-deficient children without treatment, and during two regimens of recombinant human GH (r-hGH), i.e. 2 IU/day s.c. at 08:00 h or at 20:00 h, in comparison with 5 normal, untreated children. Without treatment and when r-hGH was administered at 08:00 h, the 24-h profile of serum OC was correlated with that of the healthy controls in only 1 of 8 patients (r = 0.26 +/- 0.09 (mean +/- SE) and r = 0.10 +/- 0.08) whereas the correlation was significant in 6 of 8 patients (r = 0.44 +/- 0.05) during evening r-hGH administration. Within GH-deficient patients, mean OC level was lower during no r-hGH or evening administration compared with morning administration. In conclusion, untreated GH-deficient children have an abnormal 24-h serum OC profile. Evening administration of 2 IU of r-hGH/day s.c. tends to normalise the 24-h profile but not the average daily level, whereas morning administration of GH increases average daily OC level but does not normalize the circadian rhythm.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0956-523X
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
153-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
24-h profile of serum osteocalcin in growth hormone (GH) deficient patients with and without GH treatment.
pubmed:affiliation
University Department of Medical Endocrinology and Metabolism, Aarhus Amtssygehus, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't