Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-4-21
pubmed:abstractText
In nearly every organism studied, reduced caloric intake extends life span. In yeast, span extension from dietary restriction is thought to be mediated by the highly conserved, nutrient-responsive target of rapamycin (TOR), protein kinase A (PKA), and Sch9 kinases. These kinases coordinately regulate various cellular processes including stress responses, protein turnover, cell growth, and ribosome biogenesis. Here we show that a specific reduction of 60S ribosomal subunit levels slows aging in yeast. Deletion of genes encoding 60S subunit proteins or processing factors or treatment with a small molecule, which all inhibit 60S subunit biogenesis, are each sufficient to significantly increase replicative life span. One mechanism by which reduced 60S subunit levels leads to life span extension is through induction of Gcn4, a nutrient-responsive transcription factor. Genetic epistasis analyses suggest that dietary restriction, reduced 60S subunit abundance, and Gcn4 activation extend yeast life span by similar mechanisms.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-10198052, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-10230397, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-10436161, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-10521401, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-10604478, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-10733573, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-11000115, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-11015603, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-11024000, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-11244074, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-11292860, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-11390663, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-11583614, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-11882290, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-11893754, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-12124627, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-12509467, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-12654728, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-12676950, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-12882320, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-12890013, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-12958363, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-13666896, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-14668850, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-14741356, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-14766929, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-15068796, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-15186745, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-15226447, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-15253933, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-15314660, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-15328540, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-15466158, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-15479734, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-15620355, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-15722108, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-15885745, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-15998808, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-16012843, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-16153175, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-16256736, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-16293764, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-16418483, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-16648468, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-16651379, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-16720740, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-16741098, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-17174052, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-17266679, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-17266680, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-17277769, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-17411345, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-17521386, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-17548477, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-17560372, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-17618850, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-17941970, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-17981122, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-2038326, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-3047007, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-3346517, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-3897837, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-9461583, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-9633989, http://linkedlifedata.com/resource/pubmed/commentcorrection/18423200-9830035
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Basic-Leucine Zipper Transcription..., http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/GCN4 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases, http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/SIR2 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Silent Information Regulator..., http://linkedlifedata.com/resource/pubmed/chemical/Sirtuin 2, http://linkedlifedata.com/resource/pubmed/chemical/Sirtuins, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1097-4172
pubmed:author
More...