|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2008-6-30
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Sleep disturbances are common in critically ill patients and when sleep does occur it traverses the day-night periods. The reduction in plasma melatonin levels and loss of circadian rhythm observed in critically ill patients receiving mechanical ventilation may contribute to this irregular sleep-wake pattern. We sought to evaluate the effect of exogenous melatonin on nocturnal sleep quantity in these patients and, furthermore, to describe the kinetics of melatonin after oral administration in this patient population, thereby guiding future dosing schedules.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-10334113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-10392220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-10446827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-10668847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-10672435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-10713011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-10883420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-11227580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-11246306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-11469724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-12102248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-12598213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-12622846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-14564378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-14616429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-14675809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-14982491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-15023109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-15180493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-15196098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-15586779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-16130027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-16284208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-16473858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-16477412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-16610990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-16687277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-16774150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-16778263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-16884842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-16930101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-17334259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-17764582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-18492219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-1912128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-2745108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-3338942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-3680186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-3921096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-6463451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-6728321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-7061695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-7768078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-8127888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18423009-9656043
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1466-609X
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
12
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
R52
|
|
pubmed:dateRevised |
2010-3-23
|
|
pubmed:meshHeading |
pubmed-meshheading:18423009-Administration, Oral,
pubmed-meshheading:18423009-Aged,
pubmed-meshheading:18423009-Area Under Curve,
pubmed-meshheading:18423009-Central Nervous System Depressants,
pubmed-meshheading:18423009-Critical Illness,
pubmed-meshheading:18423009-Double-Blind Method,
pubmed-meshheading:18423009-Female,
pubmed-meshheading:18423009-Humans,
pubmed-meshheading:18423009-Intensive Care Units,
pubmed-meshheading:18423009-Linear Models,
pubmed-meshheading:18423009-Male,
pubmed-meshheading:18423009-Melatonin,
pubmed-meshheading:18423009-Middle Aged,
pubmed-meshheading:18423009-Placebos,
pubmed-meshheading:18423009-Sleep Disorders,
pubmed-meshheading:18423009-Tracheostomy,
pubmed-meshheading:18423009-Treatment Outcome
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial.
|
|
pubmed:affiliation |
Sheffield Teaching Hospitals, Critical Care Department, Northern General Hospital, Herries Road, Sheffield, UK. richard.bourne@sth.nhs.uk
|
|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
