| pubmed-article:18422761 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18422761 | lifeskim:mentions | umls-concept:C0014038 | lld:lifeskim |
| pubmed-article:18422761 | lifeskim:mentions | umls-concept:C0010097 | lld:lifeskim |
| pubmed-article:18422761 | lifeskim:mentions | umls-concept:C0162512 | lld:lifeskim |
| pubmed-article:18422761 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:18422761 | lifeskim:mentions | umls-concept:C0255808 | lld:lifeskim |
| pubmed-article:18422761 | lifeskim:mentions | umls-concept:C0255813 | lld:lifeskim |
| pubmed-article:18422761 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:18422761 | lifeskim:mentions | umls-concept:C0205202 | lld:lifeskim |
| pubmed-article:18422761 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18422761 | pubmed:dateCreated | 2008-12-16 | lld:pubmed |
| pubmed-article:18422761 | pubmed:abstractText | Differentiating between injurious and reparative factors facilitates appropriate therapeutic intervention. We evaluated the role of tumor necrosis factor alpha (TNFalpha) in parenchymal brain pathology resolution following virus-induced encephalitis from a picornavirus, Theiler's murine encephalomyelitis virus (TMEV). We infected the following animals with TMEV for 7 to 270 days: B6/129 TNF(-/-) mice (without TNFalpha expression), B6/129 TNFR1(-/-) mice (without TNFalpha receptor 1 expression), and B6/129 TNFR2(-/-) mice (without TNFalpha receptor 2 expression). Normal TNFalpha-expressing controls were TMEV-infected B6, 129/J, B6/129F1 and B6/129F2 mice. Whereas all strains developed inflammation and neuronal injury in the hippocampus and striatum 7 to 21 days postinfection (dpi), the control mice resolved the pathology by 45 to 90 dpi. However, parenchymal hippocampal and striatal injury persisted in B6/129 TNF(-/-) mice following infection. Treating virus-infected mice with active recombinant mouse TNFalpha resulted in less hippocampal and striatal pathology, whereas TNFalpha-neutralizing treatment worsened pathology. T1 "black holes" appeared on MRI during early infection in the hippocampus and striatum in all mice but persisted only in TNF(-/-) mice. TNFR2 [corrected] mediated hippocampal pathology resolution whereas TNFR1 [corrected] mediated striatal healing. These findings indicate the role of TNFalpha in resolution of sublethal hippocampal and striatal injury. | lld:pubmed |
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| pubmed-article:18422761 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18422761 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18422761 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18422761 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18422761 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18422761 | pubmed:issn | 1750-3639 | lld:pubmed |
| pubmed-article:18422761 | pubmed:author | pubmed-author:RodriguezMose... | lld:pubmed |
| pubmed-article:18422761 | pubmed:author | pubmed-author:MacuraSloboda... | lld:pubmed |
| pubmed-article:18422761 | pubmed:author | pubmed-author:ZoeckleinLaur... | lld:pubmed |
| pubmed-article:18422761 | pubmed:author | pubmed-author:GamezJeffJ | lld:pubmed |
| pubmed-article:18422761 | pubmed:author | pubmed-author:PapkeLouisaL | lld:pubmed |
| pubmed-article:18422761 | pubmed:author | pubmed-author:HoweCharlesC | lld:pubmed |
| pubmed-article:18422761 | pubmed:author | pubmed-author:DenicAleksand... | lld:pubmed |
| pubmed-article:18422761 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18422761 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:18422761 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18422761 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18422761 | pubmed:pagination | 12-26 | lld:pubmed |
| pubmed-article:18422761 | pubmed:dateRevised | 2011-8-4 | lld:pubmed |
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| pubmed-article:18422761 | pubmed:meshHeading | pubmed-meshheading:18422761... | lld:pubmed |
| pubmed-article:18422761 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18422761 | pubmed:articleTitle | Tumor necrosis factor alpha is reparative via TNFR2 [corrected] in the hippocampus and via TNFR1 [corrected] in the striatum after virus-induced encephalitis. | lld:pubmed |
| pubmed-article:18422761 | pubmed:affiliation | Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. rodriguez.moses@mayo.edu | lld:pubmed |
| pubmed-article:18422761 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18422761 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
