Linked Life Data

18418860

Source:http://linkedlifedata.com/resource/pubmed/id/18418860

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-5-5
pubmed:abstractText
Ileoanal pouch polyps commonly develop following restorative proctocolectomy in patients with familial adenomatous polyposis (FAP). In FAP adenomas, the relationship between germline and somatic adenomatous polyposis coli (APC) mutations is determined by 'just right' beta-catenin signalling in tumour cells, with respect to the 20-amino acid beta-catenin-binding/degradation repeats (20AARs) in the APC protein. However, the relationship varies, with upper gastrointestinal polyps typically retaining three to four 20AARs and colonic polyps retaining one or two. The aim of this study was to establish the mutational spectrum in ileoanal pouch polyps, to ascertain whether polyp development resembled that typical of small or large bowel.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1365-2168
pubmed:author
pubmed:copyrightInfo
2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
pubmed:issnType
Electronic
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
765-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
APC mutation spectrum in ileoanal pouch polyps resembles that of colorectal polyps.
pubmed:affiliation
Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, UK. olivia.will@cancer.org.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't