Source:http://linkedlifedata.com/resource/pubmed/id/18418798
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rdf:type | |
lifeskim:mentions |
umls-concept:C0018724,
umls-concept:C0030685,
umls-concept:C0039593,
umls-concept:C0041290,
umls-concept:C0041296,
umls-concept:C0337611,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1261322,
umls-concept:C1283071,
umls-concept:C1510438,
umls-concept:C1552644,
umls-concept:C1707455,
umls-concept:C1823153,
umls-concept:C1963578,
umls-concept:C2349976
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pubmed:issue |
5
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pubmed:dateCreated |
2008-4-17
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pubmed:abstractText |
Health care workers are at increased risk of Mycobacterium tuberculosis infection. The tuberculin skin test (TST) is frequently false positive in BCG-vaccinated health care workers. QuantiFERON-TB GOLD (QFT-G) is a sensitive and specific interferon-gamma release assay unaffected by BCG vaccination. This study compared TST and QFT-G in the diagnosis of latent TB infection in BCG-vaccinated health care workers. 39 health care workers exposed to a smear-positive TB patient were enrolled. Initial TST was positive in 33 (84.6%) cases, but only 4 (10.2%) cases using QFT-G. TST conversion occurred in 2/6 (33.3%), compared to 4/32(12.5%), cases using QFT-G. A higher proportion of QFT converters was associated with intimate contact, although not reaching statistical significance. Face-to-face contact >1 h was significantly associated with QFT-G conversion >or=0.7 IU/ml (OR 8.63, 95%CI 1.08-69.07, p=0.04). Agreement between TST and QFT-G was 18.0%, (kappa: -0.03). Concordance between TST and QFT (>or=0.35 IU/ml) conversion was 40.0%(kappa=-0.40), and 60.0%(kappa=0.00) if QFT >or=0.7 IU/ml was used. Agreement increased with increasing TST cut-offs. TST is not useful in contact investigation among BCG-vaccinated health care workers, in an area with intermediate burden of TB. QFT may provide additional information for the diagnosis and strategic management of preventive treatment of LTBI in BCG-vaccinated health care workers in a country with intermediate burden of TB.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0036-5548
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
373-80
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18418798-Health Personnel,
pubmed-meshheading:18418798-Humans,
pubmed-meshheading:18418798-Interferon-gamma,
pubmed-meshheading:18418798-Male,
pubmed-meshheading:18418798-Middle Aged,
pubmed-meshheading:18418798-Mycobacterium bovis,
pubmed-meshheading:18418798-Mycobacterium tuberculosis,
pubmed-meshheading:18418798-Occupational Exposure,
pubmed-meshheading:18418798-Predictive Value of Tests,
pubmed-meshheading:18418798-Skin Tests,
pubmed-meshheading:18418798-Tuberculin Test,
pubmed-meshheading:18418798-Tuberculosis
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pubmed:year |
2008
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pubmed:articleTitle |
Comparison of the interferon- gamma release assay and the tuberculin skin test for contact investigation of tuberculosis in BCG-vaccinated health care workers.
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pubmed:affiliation |
Section of Infectious Diseases and Microbiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Case Reports,
Research Support, Non-U.S. Gov't
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