| pubmed-article:18417224 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18417224 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18417224 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:18417224 | lifeskim:mentions | umls-concept:C0599779 | lld:lifeskim |
| pubmed-article:18417224 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:18417224 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:18417224 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:18417224 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:18417224 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18417224 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:18417224 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:18417224 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18417224 | pubmed:dateCreated | 2008-5-26 | lld:pubmed |
| pubmed-article:18417224 | pubmed:abstractText | Interleukin-2 (IL-2) plays an established role in T-cell regulation through binding to the high-affinity IL-2 receptor (IL-2R). The alpha-chain encoded by the IL2RA (CD25) gene is a substantial component of the high-affinity receptor molecule highly expressed by activated T lymphocytes. Recently, a strong evidence was obtained for the involvement of IL-2RA in conferring susceptibility to type 1 diabetes (T1D). Significant association with T1D was also found in the region on chromosome 4q27 containing the IL2 gene and homologous to the susceptibility locus idd3 in non-obese diabetic (NOD) mice, an animal model for human T1D. Here we focus on the discussion of these new findings suggesting for a crucial role of IL-2/IL-2RA-mediated regulatory mechanisms in preventing T1D. The non-redundant role of IL-2 and its receptor in etiology of T1D could be particularly attributable to the regulation of CD4+ CD25+ regulatory T cells, whose function is critical in maintaining immune homeostasis. | lld:pubmed |
| pubmed-article:18417224 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18417224 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18417224 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18417224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18417224 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18417224 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18417224 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18417224 | pubmed:issn | 0165-2478 | lld:pubmed |
| pubmed-article:18417224 | pubmed:author | pubmed-author:ChistiakovDim... | lld:pubmed |
| pubmed-article:18417224 | pubmed:author | pubmed-author:VoronovaNatal... | lld:pubmed |
| pubmed-article:18417224 | pubmed:author | pubmed-author:ChistiakovPav... | lld:pubmed |
| pubmed-article:18417224 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18417224 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18417224 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:18417224 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18417224 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18417224 | pubmed:pagination | 1-5 | lld:pubmed |
| pubmed-article:18417224 | pubmed:meshHeading | pubmed-meshheading:18417224... | lld:pubmed |
| pubmed-article:18417224 | pubmed:meshHeading | pubmed-meshheading:18417224... | lld:pubmed |
| pubmed-article:18417224 | pubmed:meshHeading | pubmed-meshheading:18417224... | lld:pubmed |
| pubmed-article:18417224 | pubmed:meshHeading | pubmed-meshheading:18417224... | lld:pubmed |
| pubmed-article:18417224 | pubmed:meshHeading | pubmed-meshheading:18417224... | lld:pubmed |
| pubmed-article:18417224 | pubmed:meshHeading | pubmed-meshheading:18417224... | lld:pubmed |
| pubmed-article:18417224 | pubmed:meshHeading | pubmed-meshheading:18417224... | lld:pubmed |
| pubmed-article:18417224 | pubmed:meshHeading | pubmed-meshheading:18417224... | lld:pubmed |
| pubmed-article:18417224 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18417224 | pubmed:articleTitle | The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies. | lld:pubmed |
| pubmed-article:18417224 | pubmed:affiliation | Department of Pathology, University of Pittsburgh Medical Center, A719 Scaife Hall, Pittsburgh, PA 15261, USA. dimitry.chistiakov@eudoramail.com | lld:pubmed |
| pubmed-article:18417224 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18417224 | pubmed:publicationType | Review | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18417224 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18417224 | lld:pubmed |
