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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-4-16
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pubmed:abstractText |
The lipopolysaccharide (LPS)-triggered release of inflammatory cytokines from Kupffer cells is mediated via the CD14/TLR4 receptor complex. This inflammatory pathway can be influenced by alterations in genes encoding for LPS receptor components. Thus, a -260 C>T transition in the CD14 promoter is thought to result in enhanced CD14 expression thereby increasing the LPS responsiveness in chronic liver diseases, whereas a D299G exchange in the TLR4 gene has the opposite effect. Our objective was to analyze these two variations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1502-7708
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pubmed:author |
pubmed-author:BergThomasT,
pubmed-author:BeuersUlrichU,
pubmed-author:HalangkJulianeJ,
pubmed-author:NeuhausPeterP,
pubmed-author:NeumannKonradK,
pubmed-author:NickelRenateR,
pubmed-author:PuhlGeroG,
pubmed-author:TuboiSS,
pubmed-author:Von HahnThomasT,
pubmed-author:WiedenmannBertramB,
pubmed-author:WittHeikoH
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pubmed:issnType |
Electronic
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
584-92
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18415752-Adolescent,
pubmed-meshheading:18415752-Adult,
pubmed-meshheading:18415752-Aged,
pubmed-meshheading:18415752-Antigens, CD14,
pubmed-meshheading:18415752-Child,
pubmed-meshheading:18415752-Chronic Disease,
pubmed-meshheading:18415752-Female,
pubmed-meshheading:18415752-Genetic Predisposition to Disease,
pubmed-meshheading:18415752-Genetic Variation,
pubmed-meshheading:18415752-Genotype,
pubmed-meshheading:18415752-Hepatitis C, Chronic,
pubmed-meshheading:18415752-Humans,
pubmed-meshheading:18415752-Liver Diseases,
pubmed-meshheading:18415752-Liver Diseases, Alcoholic,
pubmed-meshheading:18415752-Male,
pubmed-meshheading:18415752-Middle Aged,
pubmed-meshheading:18415752-Receptors, Immunologic,
pubmed-meshheading:18415752-Toll-Like Receptor 4
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pubmed:year |
2008
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pubmed:articleTitle |
Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease.
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pubmed:affiliation |
Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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