| pubmed-article:18413717 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18413717 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:18413717 | lifeskim:mentions | umls-concept:C0035678 | lld:lifeskim |
| pubmed-article:18413717 | lifeskim:mentions | umls-concept:C0070828 | lld:lifeskim |
| pubmed-article:18413717 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:18413717 | lifeskim:mentions | umls-concept:C1549081 | lld:lifeskim |
| pubmed-article:18413717 | lifeskim:mentions | umls-concept:C1692758 | lld:lifeskim |
| pubmed-article:18413717 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:18413717 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18413717 | pubmed:dateCreated | 2008-4-16 | lld:pubmed |
| pubmed-article:18413717 | pubmed:abstractText | During transcription termination by RNA polymerase II on protein-coding genes, the nuclear 5' exonuclease Rat1/Xrn2 degrades the nascent transcript downstream from the polyadenylation site and "torpedoes" the polymerase. We report that the activity of Rat1 is also required for efficient termination by RNA polymerase I (Pol I) on the rDNA. In strains lacking catalytically active Rat1 or its cofactor Rai1, Pol I reads through the major, "Reb1-dependent" terminator (T1) but stops downstream at the "fail-safe" terminator (T2) and replication fork barrier (RFB). The absence of both Rat1 and the RFB-binding protein Fob1 increased Pol I read-through of T2 and the RFB. We propose that cotranscriptional cleavage of the pre-rRNA by the endonuclease Rnt1 generates a loading site for the Rat1/Rai1 complex, which then degrades the nascent transcript. When Rat1 catches Pol I, which is predicted to be paused at T1, transcription is terminated. | lld:pubmed |
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| pubmed-article:18413717 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18413717 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18413717 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18413717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18413717 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18413717 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18413717 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:18413717 | pubmed:author | pubmed-author:TollerveyDavi... | lld:pubmed |
| pubmed-article:18413717 | pubmed:author | pubmed-author:KufelJoannaJ | lld:pubmed |
| pubmed-article:18413717 | pubmed:author | pubmed-author:KolárMichalM | lld:pubmed |
| pubmed-article:18413717 | pubmed:author | pubmed-author:El HageAzizA | lld:pubmed |
| pubmed-article:18413717 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18413717 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18413717 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:18413717 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18413717 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18413717 | pubmed:pagination | 1069-81 | lld:pubmed |
| pubmed-article:18413717 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18413717 | pubmed:meshHeading | pubmed-meshheading:18413717... | lld:pubmed |
| pubmed-article:18413717 | pubmed:meshHeading | pubmed-meshheading:18413717... | lld:pubmed |
| pubmed-article:18413717 | pubmed:meshHeading | pubmed-meshheading:18413717... | lld:pubmed |
| pubmed-article:18413717 | pubmed:meshHeading | pubmed-meshheading:18413717... | lld:pubmed |
| pubmed-article:18413717 | pubmed:meshHeading | pubmed-meshheading:18413717... | lld:pubmed |
| pubmed-article:18413717 | pubmed:meshHeading | pubmed-meshheading:18413717... | lld:pubmed |
| pubmed-article:18413717 | pubmed:meshHeading | pubmed-meshheading:18413717... | lld:pubmed |
| pubmed-article:18413717 | pubmed:meshHeading | pubmed-meshheading:18413717... | lld:pubmed |
| pubmed-article:18413717 | pubmed:meshHeading | pubmed-meshheading:18413717... | lld:pubmed |
| pubmed-article:18413717 | pubmed:meshHeading | pubmed-meshheading:18413717... | lld:pubmed |
| pubmed-article:18413717 | pubmed:meshHeading | pubmed-meshheading:18413717... | lld:pubmed |
| pubmed-article:18413717 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18413717 | pubmed:articleTitle | Efficient termination of transcription by RNA polymerase I requires the 5' exonuclease Rat1 in yeast. | lld:pubmed |
| pubmed-article:18413717 | pubmed:affiliation | Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom. | lld:pubmed |
| pubmed-article:18413717 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18413717 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
