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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-7-2
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pubmed:abstractText |
Genetic testing for the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 has important implications for the clinical management of people found to carry a mutation. However, genetic testing is expensive and may be associated with adverse psychosocial effects. To provide a cost-efficient and clinically appropriate genetic counselling service, genetic testing should be targeted at those individuals most likely to carry pathogenic mutations. Several algorithms that predict the likelihood of carrying a BRCA1 or a BRCA2 mutation are currently used in clinical practice to identify such individuals.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1468-6244
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pubmed:author |
pubmed-author:AntoniouA CAC,
pubmed-author:DouglasFF,
pubmed-author:EastonD FDF,
pubmed-author:EcclesDD,
pubmed-author:EelesRR,
pubmed-author:EvansD GDG,
pubmed-author:HardyRR,
pubmed-author:IzattLL,
pubmed-author:MorrisonP JPJ,
pubmed-author:PharoahP D PPD,
pubmed-author:PichertGG,
pubmed-author:RossAA,
pubmed-author:ScottJJ,
pubmed-author:ShanleySS,
pubmed-author:ShentonAA,
pubmed-author:WalkerLL,
pubmed-author:ZimmernR LRL
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pubmed:issnType |
Electronic
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
425-31
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18413374-Algorithms,
pubmed-meshheading:18413374-Breast Neoplasms,
pubmed-meshheading:18413374-Female,
pubmed-meshheading:18413374-Genes, BRCA1,
pubmed-meshheading:18413374-Genes, BRCA2,
pubmed-meshheading:18413374-Genetic Counseling,
pubmed-meshheading:18413374-Genetic Predisposition to Disease,
pubmed-meshheading:18413374-Genetic Testing,
pubmed-meshheading:18413374-Humans,
pubmed-meshheading:18413374-Models, Statistical,
pubmed-meshheading:18413374-Ovarian Neoplasms,
pubmed-meshheading:18413374-Predictive Value of Tests,
pubmed-meshheading:18413374-ROC Curve,
pubmed-meshheading:18413374-Sensitivity and Specificity
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pubmed:year |
2008
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pubmed:articleTitle |
Predicting the likelihood of carrying a BRCA1 or BRCA2 mutation: validation of BOADICEA, BRCAPRO, IBIS, Myriad and the Manchester scoring system using data from UK genetics clinics.
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pubmed:affiliation |
Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK. antonis@srl.cam.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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