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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-10-28
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pubmed:abstractText |
The risk of diabetic nephropathy (DN) can be increased by elevated intraglomerular pressure and glomerular filtration rate, leading to glomerular damage. This can be controlled by the renin-angiotensin-aldosterone (RAA) system, which has an important function regulating both systemic and intrarenal blood pressure. Smoking increases the risk of DN, but not all diabetic patients who smoke develop DN. There is a possibility that smoking has different effects depending on the different genotypes of the individual. We investigated the association of DN with seven polymorphisms in the RAA system and their possible interaction with smoking.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1873-460X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
377-83
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pubmed:meshHeading |
pubmed-meshheading:18413189-Adult,
pubmed-meshheading:18413189-Albuminuria,
pubmed-meshheading:18413189-Alleles,
pubmed-meshheading:18413189-Diabetes Mellitus, Type 1,
pubmed-meshheading:18413189-Diabetic Nephropathies,
pubmed-meshheading:18413189-Female,
pubmed-meshheading:18413189-Genetic Predisposition to Disease,
pubmed-meshheading:18413189-Genotype,
pubmed-meshheading:18413189-Hemoglobin A, Glycosylated,
pubmed-meshheading:18413189-Homozygote,
pubmed-meshheading:18413189-Humans,
pubmed-meshheading:18413189-Male,
pubmed-meshheading:18413189-Microsatellite Repeats,
pubmed-meshheading:18413189-Middle Aged,
pubmed-meshheading:18413189-Polymorphism, Genetic,
pubmed-meshheading:18413189-Polymorphism, Single Nucleotide,
pubmed-meshheading:18413189-Receptor, Angiotensin, Type 1,
pubmed-meshheading:18413189-Renin-Angiotensin System,
pubmed-meshheading:18413189-Smoking
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pubmed:articleTitle |
The effect of polymorphisms in the renin-angiotensin-aldosterone system on diabetic nephropathy risk.
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pubmed:affiliation |
Department of Clinical Sciences, Paediatrics, Umeå University, Umeå, Sweden. anna.mollsten@pediatri.umu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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