Linked Life Data

18411021

Source:http://linkedlifedata.com/resource/pubmed/id/18411021

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-6-16
pubmed:abstractText
In this study we intended to evaluate the cytotoxic and genotoxic effects of trimethyltin chloride (TMT), one of the most widely used organometallic compounds, on liver cells with the rat liver epithelial cell line IAR20. The results showed that TMT significantly inhibited cell growth in a concentration-dependent manner and caused an increase in DNA damage. Additionally, Hoechst 33342 staining and flow cytometry detected increases in apoptotic and necrotic cells. Western blots demonstrated that the Bcl-2 family of proteins was involved in the apoptotic process, but p53 was not concerned.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0887-2333
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1136-42
pubmed:dateRevised
2009-4-10
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The concentration-dependent induction of cell death by trimethyltin chloride in rat liver epithelial IAR20 cells.
pubmed:affiliation
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Siming South Road, Xiamen City 361005, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't