Linked Life Data

18410908

Source:http://linkedlifedata.com/resource/pubmed/id/18410908

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-5-12
pubmed:abstractText
Neurons that utilize melanin-concentrating hormone (MCH) as a neuromodulator are localized within the postero-lateral hypothalamus and zona incerta. These neurons project diffusely throughout the central nervous system and have been implicated in critical physiological processes such as energy homeostasis and sleep. In the present report, we examined the distribution of MCH immunoreactivity in the brainstem of the cat. In addition to MCH+ axons, we found MCH-immunoreactive cells that have not been previously described either in the midbrain raphe nuclei or in the periaqueductal and periventricular areas. These MCH+ cells constituted: 1. ependymal cells that lined the fourth ventricle and aqueduct, 2. ependymal cells with long basal processes that projected deeply into the subventricular (subaqueductal) parenchyma, and, 3. cells in subventricular regions and the midbrain raphe nuclei. The MCH+ cells in the midbrain raphe nuclei were closely related to neuronal processes of serotonergic neurons. Utilizing Neu-N and GFAP immunohistochemistry we determined that the preceding MCH+ cells were neither neurons nor astrocytes. However, we found that vimentin, an intermediate-filament protein that is used as a marker for tanycytes, was specifically co-localized with MCH in these cells. We conclude that MCH is present in tanycytes whose processes innervate the midbrain raphe nuclei and adjacent subependymal regions. Because tanycytes are specialized cells that transport substances from the cerebrospinal fluid (CSF) to neural parenchyma, we suggest that MCH is absorbed from the CSF by tanycytes and subsequently liberate to act upon neurons of brainstem nuclei.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
1210
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
163-78
pubmed:meshHeading
pubmed-meshheading:18410908-Animals, pubmed-meshheading:18410908-Brain Mapping, pubmed-meshheading:18410908-Brain Stem, pubmed-meshheading:18410908-Cats, pubmed-meshheading:18410908-Cerebral Aqueduct, pubmed-meshheading:18410908-Cerebrospinal Fluid, pubmed-meshheading:18410908-Ependyma, pubmed-meshheading:18410908-Fourth Ventricle, pubmed-meshheading:18410908-Glial Fibrillary Acidic Protein, pubmed-meshheading:18410908-Hypothalamic Hormones, pubmed-meshheading:18410908-Immunohistochemistry, pubmed-meshheading:18410908-Male, pubmed-meshheading:18410908-Melanins, pubmed-meshheading:18410908-Nerve Tissue Proteins, pubmed-meshheading:18410908-Neuroglia, pubmed-meshheading:18410908-Nuclear Proteins, pubmed-meshheading:18410908-Pituitary Hormones, pubmed-meshheading:18410908-Raphe Nuclei, pubmed-meshheading:18410908-Vimentin
pubmed:year
2008
pubmed:articleTitle
Melanin-concentrating hormone (MCH) immunoreactivity in non-neuronal cells within the raphe nuclei and subventricular region of the brainstem of the cat.
pubmed:affiliation
Departamento de Fisiología, Facultad de Medicina, Universidad de la República, General Flores 2125, 11800 Montevideo, Uruguay.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural