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pubmed-article:18410469pubmed:abstractTextActivation of latent transforming growth factor (TGF)-beta in seminal plasma has been suggested by Robertson et al. to promote maternal tolerance to paternal antigens. A possible consequence reported by Tremellen et al. is increased pregnancy rates in women undergoing IVF. A decreased spontaneous abortion rate has also been postulated. Seminal plasma contains many factors besides TGF-beta, and a critical test of the hypothesis was required. The purpose of the present study was to directly test the effect of pure TGF-beta.lld:pubmed
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pubmed-article:18410469pubmed:dateRevised2008-8-7lld:pubmed
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pubmed-article:18410469pubmed:articleTitlePrevention of spontaneous abortion in the CBA x DBA/2 mouse model by intravaginal TGF-beta and local recruitment of CD4+8+ FOXP3+ cells.lld:pubmed
pubmed-article:18410469pubmed:affiliationDepartment of Medicine, McMaster University, Hamilton, ON, Canada. clarkd@mcmaster.calld:pubmed
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pubmed-article:18410469pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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