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rdf:type |
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lifeskim:mentions |
umls-concept:C0000786,
umls-concept:C0007634,
umls-concept:C0025922,
umls-concept:C0026336,
umls-concept:C0040690,
umls-concept:C0205276,
umls-concept:C0271510,
umls-concept:C1332714,
umls-concept:C1416467,
umls-concept:C1511649,
umls-concept:C1708528
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|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2008-5-16
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|
pubmed:abstractText |
Activation of latent transforming growth factor (TGF)-beta in seminal plasma has been suggested by Robertson et al. to promote maternal tolerance to paternal antigens. A possible consequence reported by Tremellen et al. is increased pregnancy rates in women undergoing IVF. A decreased spontaneous abortion rate has also been postulated. Seminal plasma contains many factors besides TGF-beta, and a critical test of the hypothesis was required. The purpose of the present study was to directly test the effect of pure TGF-beta.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1046-7408
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
59
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
525-34
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pubmed:dateRevised |
2008-8-7
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pubmed:meshHeading |
pubmed-meshheading:18410469-Abortion, Spontaneous,
pubmed-meshheading:18410469-Administration, Intravaginal,
pubmed-meshheading:18410469-Animals,
pubmed-meshheading:18410469-Antigens, CD4,
pubmed-meshheading:18410469-Antigens, CD8,
pubmed-meshheading:18410469-Disease Models, Animal,
pubmed-meshheading:18410469-Female,
pubmed-meshheading:18410469-Forkhead Transcription Factors,
pubmed-meshheading:18410469-Immunohistochemistry,
pubmed-meshheading:18410469-Male,
pubmed-meshheading:18410469-Mice,
pubmed-meshheading:18410469-Mice, Inbred BALB C,
pubmed-meshheading:18410469-Mice, Inbred CBA,
pubmed-meshheading:18410469-Mice, Inbred DBA,
pubmed-meshheading:18410469-Pregnancy,
pubmed-meshheading:18410469-Pregnancy, Animal,
pubmed-meshheading:18410469-T-Lymphocytes, Regulatory,
pubmed-meshheading:18410469-Transforming Growth Factor beta3
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pubmed:year |
2008
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pubmed:articleTitle |
Prevention of spontaneous abortion in the CBA x DBA/2 mouse model by intravaginal TGF-beta and local recruitment of CD4+8+ FOXP3+ cells.
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pubmed:affiliation |
Department of Medicine, McMaster University, Hamilton, ON, Canada. clarkd@mcmaster.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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