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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-1-13
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pubmed:abstractText |
Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRgamma-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1440-1789
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pubmed:author |
pubmed-author:HashinoSatoshiS,
pubmed-author:ItohTomooT,
pubmed-author:KimuraTaichiT,
pubmed-author:LeiWangW,
pubmed-author:MarukawaKatsujiK,
pubmed-author:NagashimaKazuoK,
pubmed-author:NishiharaHiroshiH,
pubmed-author:TakiyamaAkihiroA,
pubmed-author:TanakaShinyaS,
pubmed-author:TateishiUkihideU,
pubmed-author:WangLeiL
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
640-4
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pubmed:dateRevised |
2010-7-16
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pubmed:meshHeading |
pubmed-meshheading:18410281-Bone Marrow,
pubmed-meshheading:18410281-Brain Neoplasms,
pubmed-meshheading:18410281-Cell Nucleus Shape,
pubmed-meshheading:18410281-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:18410281-Genes, T-Cell Receptor gamma,
pubmed-meshheading:18410281-Humans,
pubmed-meshheading:18410281-Lymph Nodes,
pubmed-meshheading:18410281-Lymphoma, T-Cell, Peripheral,
pubmed-meshheading:18410281-Lymphomatoid Granulomatosis,
pubmed-meshheading:18410281-Magnetic Resonance Imaging,
pubmed-meshheading:18410281-Male,
pubmed-meshheading:18410281-Middle Aged,
pubmed-meshheading:18410281-Polymerase Chain Reaction,
pubmed-meshheading:18410281-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:18410281-T-Lymphocytes
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pubmed:year |
2008
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pubmed:articleTitle |
CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements.
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pubmed:affiliation |
Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, Kita-Ku, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Case Reports
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