Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2008-6-2
pubmed:abstractText
It has been reported previously that cyclin G1 enables cells to overcome radiation-induced G(2) arrest and increased cell death and that these effects are mediated by transcriptional activation of cyclin B1. In this study, we further investigated the mechanism by which cyclin G1 transcriptionally activates cyclin B1. Deletion or point mutations within the cyclin B1 promoter region revealed that the c-Myc binding site (E-box) is necessary for cyclin G1-mediated transcriptional activation of cyclin B1 to occur. In addition, the kinase activity of Cdk5 was increased by cyclin G1 overexpression, and Cdk5 directly phosphorylated c-Myc on Ser-62. Furthermore, cyclin G1 mediated increased radiosensitivity, and radiation-induced M phase arrest was attenuated when RNA interference of Cdk5 was treated. Taken together, the results of this study indicate that Cdk5 activation in cells that overexpress cyclin G1 leads to c-Myc phosphorylation on Ser-62, which is responsible for cyclin G1-mediated transcriptional activation of cyclin B1.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-10022608, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-10078200, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-10196184, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-10378689, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-10378690, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-10378696, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-10467405, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-10592328, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-10825194, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-10913183, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-11068036, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-11314049, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-11522645, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-11765061, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-11893238, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-11983916, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-12167164, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-12634633, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-12676581, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-1423612, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-1530948, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-16322753, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-16483932, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-2206213, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-7556094, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-7585620, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-7739559, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-7775458, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-7784084, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-7957050, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-7997877, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-8035827, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-8134878, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-8164695, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-8247524, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-8302604, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-8712067, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-8806701, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-8808703, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-8887688, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-8895573, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-9013707, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-9013862, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-9039258, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-9139721, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-9208611, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-9299234, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-9675819, http://linkedlifedata.com/resource/pubmed/commentcorrection/18408012-9696022
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
283
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15601-10
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1.
pubmed:affiliation
Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't