Source:http://linkedlifedata.com/resource/pubmed/id/18407913
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2008-4-14
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pubmed:abstractText |
Emodin is a commonly used traditional herbal treatment in China, including use for pancreatic malignancy. In this study, the potential for emodin to inhibit pancreatic cancer cell proliferation was examined using 4 human pancreatic adenocarcinoma cell lines: Mia Paca-2, BxPC-3, Panc-1, and L3.6pl. WST-1 proliferation, propidium iodide flow cytometry cell cycle analysis, and poly-ADP-ribose polymerase (PARP) Western blot analysis were performed. Forty-eight-hour treatment with 50 muM emodin inhibited proliferation in Mia Paca-2 cells by 42%, BxPc-3 by 38%, L3.6pl by 56%, and Panc-1 by 18% (all P < .01). In three-fourths of the cell lines, emodin treatment resulted in an increase (from 4.7% to 22%) in the cell population number in apoptosis when measured by flow cytometric analysis. Mia Paca-2 revealed a significant PARP cleavage product when compared with control. These feasibility experiments provide initial evidence that emodin exerts an antiproliferative effect, likely through apoptosis induction-related mechanism(s), that is reproducible in various human pancreatic cancer cell lines.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0148-6071
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
190-6
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pubmed:meshHeading |
pubmed-meshheading:18407913-Adenocarcinoma,
pubmed-meshheading:18407913-Apoptosis,
pubmed-meshheading:18407913-Blotting, Western,
pubmed-meshheading:18407913-Cell Cycle,
pubmed-meshheading:18407913-Cell Line, Tumor,
pubmed-meshheading:18407913-Cell Proliferation,
pubmed-meshheading:18407913-Dose-Response Relationship, Drug,
pubmed-meshheading:18407913-Emodin,
pubmed-meshheading:18407913-Flow Cytometry,
pubmed-meshheading:18407913-Humans,
pubmed-meshheading:18407913-Pancreas,
pubmed-meshheading:18407913-Pancreatic Neoplasms,
pubmed-meshheading:18407913-Protein Kinase Inhibitors,
pubmed-meshheading:18407913-Rheum,
pubmed-meshheading:18407913-Treatment Outcome
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pubmed:articleTitle |
Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro.
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pubmed:affiliation |
Department of Surgery, The University of Illinois at Chicago, USA.
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pubmed:publicationType |
Journal Article
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