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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-5-30
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pubmed:abstractText |
We present a new model-based framework for the statistical analysis of diffusion imaging data associated with specific white matter tracts. The framework takes advantage of the fact that several of the major white matter tracts are thin sheet-like structures that can be effectively modeled by medial representations. The approach involves segmenting major tracts and fitting them with deformable geometric medial models. The medial representation makes it possible to average and combine tensor-based features along directions locally perpendicular to the tracts, thus reducing data dimensionality and accounting for errors in normalization. The framework enables the analysis of individual white matter structures, and provides a range of possibilities for computing statistics and visualizing differences between cohorts. The framework is demonstrated in a study of white matter differences in pediatric chromosome 22q11.2 deletion syndrome.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AG027785,
http://linkedlifedata.com/resource/pubmed/grant/HD042974,
http://linkedlifedata.com/resource/pubmed/grant/HD046159,
http://linkedlifedata.com/resource/pubmed/grant/K25 AG027785-01A1,
http://linkedlifedata.com/resource/pubmed/grant/MH068066,
http://linkedlifedata.com/resource/pubmed/grant/NS045839,
http://linkedlifedata.com/resource/pubmed/grant/NS061111,
http://linkedlifedata.com/resource/pubmed/grant/P30 NS045839-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 HD042974-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 HD046159-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 MH068066-04,
http://linkedlifedata.com/resource/pubmed/grant/R21 NS061111-01
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-10468624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-10628945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-10698817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-10860804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-11222460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-11313035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-11573002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-11747097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-11810663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-12071624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-12270226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-12391568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-12489103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-14645885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-15501083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-15501084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-15734353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-15906294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-15907311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-16156359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-16545965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-16624579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-16768234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-16788917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-16919971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-16926104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-17151168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-17167991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-17804278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-18041267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-18041271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-8019776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-9533596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-9873911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-9931269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18407524-9989633
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1053-8119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
448-61
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pubmed:dateRevised |
2011-5-19
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
Structure-specific statistical mapping of white matter tracts.
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pubmed:affiliation |
Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA. pauly2@mail.med.upenn.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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