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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-5-6
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pubmed:abstractText |
Folate is an important micronutrient molecule participating in DNA synthesis, methylation and repair mechanisms. Genetic polymorphisms in folate pathway related enzymes including methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, thymidylate synthase (TS) 28-bp tandem repeat, and reduced folate carrier (RFC) G80A have been shown to be associated with increased susceptibility for several cancers. The aim of the present study was to evaluate whether single nucleotide polymorphisms in the genes encoding enzymes of the folate pathway predispose to any CNS tumors in Thai children.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1525-1500
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
72-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18406541-5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase,
pubmed-meshheading:18406541-Case-Control Studies,
pubmed-meshheading:18406541-Central Nervous System Neoplasms,
pubmed-meshheading:18406541-Child,
pubmed-meshheading:18406541-Female,
pubmed-meshheading:18406541-Folic Acid,
pubmed-meshheading:18406541-Humans,
pubmed-meshheading:18406541-Male,
pubmed-meshheading:18406541-Membrane Transport Proteins,
pubmed-meshheading:18406541-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:18406541-Polymorphism, Genetic,
pubmed-meshheading:18406541-Reduced Folate Carrier Protein,
pubmed-meshheading:18406541-Thailand,
pubmed-meshheading:18406541-Thymidylate Synthase
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pubmed:year |
2008
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pubmed:articleTitle |
Folate pathway genetic polymorphisms and susceptibility of central nervous system tumors in Thai children.
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pubmed:affiliation |
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok 10400, Thailand.
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pubmed:publicationType |
Journal Article
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