| pubmed-article:18406348 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18406348 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18406348 | lifeskim:mentions | umls-concept:C1622340 | lld:lifeskim |
| pubmed-article:18406348 | lifeskim:mentions | umls-concept:C0010467 | lld:lifeskim |
| pubmed-article:18406348 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:18406348 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18406348 | pubmed:dateCreated | 2008-5-5 | lld:pubmed |
| pubmed-article:18406348 | pubmed:abstractText | Bovine adrenal zona fasciculata (AZF) cells express bTREK-1 K(+) channels that set the resting membrane potential. Inhibition of these channels by adrenocorticotropic hormone (ACTH) is coupled to membrane depolarization and cortisol secretion. Curcumin, a phytochemical with medicinal properties extracted from the spice turmeric, was found to modulate both bTREK-1 K(+) currents and cortisol secretion from AZF cells. In whole-cell patch clamp experiments, curcumin inhibited bTREK-1 with an IC(50) of 0.93muM by a mechanism that was voltage-independent. bTREK-1 inhibition by curcumin occurred through interaction with an external binding site and was independent of ATP hydrolysis. Curcumin produced a concentration-dependent increase in cortisol secretion that persisted for up to 24h. At a maximally effective concentration of 50muM, curcumin increased secretion as much as 10-fold. These results demonstrate that curcumin potently inhibits bTREK-1 K(+) channels and stimulates cortisol secretion from bovine AZF cells. The inhibition of bTREK-1 by curcumin may be linked to cortisol secretion through membrane depolarization. Since TREK-1 is widely expressed in a variety of cells, it is likely that some of the biological actions of curcumin, including its therapeutic effects, may be mediated through inhibition of these K(+) channels. | lld:pubmed |
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| pubmed-article:18406348 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18406348 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18406348 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18406348 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18406348 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18406348 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:18406348 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:18406348 | pubmed:author | pubmed-author:PorcoJohn... | lld:pubmed |
| pubmed-article:18406348 | pubmed:author | pubmed-author:LiuHaiyanH | lld:pubmed |
| pubmed-article:18406348 | pubmed:author | pubmed-author:EnyeartJudith... | lld:pubmed |
| pubmed-article:18406348 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18406348 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:18406348 | pubmed:volume | 370 | lld:pubmed |
| pubmed-article:18406348 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18406348 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18406348 | pubmed:pagination | 623-8 | lld:pubmed |
| pubmed-article:18406348 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:18406348 | pubmed:meshHeading | pubmed-meshheading:18406348... | lld:pubmed |
| pubmed-article:18406348 | pubmed:meshHeading | pubmed-meshheading:18406348... | lld:pubmed |
| pubmed-article:18406348 | pubmed:meshHeading | pubmed-meshheading:18406348... | lld:pubmed |
| pubmed-article:18406348 | pubmed:meshHeading | pubmed-meshheading:18406348... | lld:pubmed |
| pubmed-article:18406348 | pubmed:meshHeading | pubmed-meshheading:18406348... | lld:pubmed |
| pubmed-article:18406348 | pubmed:meshHeading | pubmed-meshheading:18406348... | lld:pubmed |
| pubmed-article:18406348 | pubmed:meshHeading | pubmed-meshheading:18406348... | lld:pubmed |
| pubmed-article:18406348 | pubmed:meshHeading | pubmed-meshheading:18406348... | lld:pubmed |
| pubmed-article:18406348 | pubmed:meshHeading | pubmed-meshheading:18406348... | lld:pubmed |
| pubmed-article:18406348 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18406348 | pubmed:articleTitle | Curcumin inhibits bTREK-1 K+ channels and stimulates cortisol secretion from adrenocortical cells. | lld:pubmed |
| pubmed-article:18406348 | pubmed:affiliation | Department of Neuroscience, The Ohio State University, College of Medicine and Public Health, 5196 Graves Hall, 333 W.10th Avenue, Columbus, OH 43210-1239, USA. enyeart.1@osu.edu | lld:pubmed |
| pubmed-article:18406348 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18406348 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
